Table 3 Prediction of effect of SNPs on physicochemical properties of mutated proteins
# | SNP ID | No. of amino acids | Mol. Wt | pI | Half life (hours) | Ext. coefficient (M−1cm−1) | Aliphatic index | Instability index | GRAVY |
|---|---|---|---|---|---|---|---|---|---|
ESR1 | |||||||||
 1 | Normal | 649 | 72,431.96 | 5.48 | 30 | 62,520 | 73.70 | 42.52 | -0.499 |
 2 | rs1583384537 | 649 | 72,431.01 | 5.56 | 30 | 62,520 | 73.70 | 42.75 | -0.500 |
 3 | rs1554259481 | 90 | 9722.94 | 5.20 | 30 | 8940 | 73.89 | 17.52 | -0.461 |
 4 | rs104893956 | 164 | 17,655.67 | 4.73 | 30 | 14,900 | 67.93 | 41.73 | -0.496 |
 5 | rs761613029 | 649 | 72,430.97 | 5.52 | 30 | 62,520 | 73.70 | 42.52 | -0.499 |
 6 | rs778449608 | 649 | 72,431.01 | 5.56 | 30 | 62,520 | 73.70 | 42.50 | -0.500 |
 7 | rs866869178 | 649 | 72,403.90 | 5.43 | 30 | 62,520 | 73.70 | 41.75 | -0.497 |
 8 | rs188957694 | 649 | 72,372.88 | 5.43 | 30 | 62,520 | 73.70 | 41.90 | -0.494 |
 9 | rs755667747 | 318 | 35,092.17 | 6.67 | 30 | 35,340 | 51.04 | 46.66 | -0.820 |
 10 | rs1467954450 | 369 | 40,674.70 | 6.22 | 30 | 36,830 | 57.99 | 46.27 | -0.727 |
 11 | rs1584799119 | 649 | 72,430.97 | 5.52 | 30 | 62,520 | 73.70 | 42.77 | -0.499 |
 12 | rs1131692059 | 649 | 72,412.91 | 5.47 | 30 | 62,520 | 73.70 | 42.20 | -0.497 |
 13 | rs762742833 | 520 | 58,068.64 | 5.31 | 30 | 56,560 | 69.27 | 43.04 | -0.537 |
 14 | rs758798083 | 649 | 72,432.94 | 5.43 | 30 | 62,520 | 73.70 | 42.02 | -0.499 |
 15 | rs1253340312 | 535 | 60,744.21 | 6.16 | 30 | 50,725 | 75.50 | 45.06 | -0.554 |
 16 | rs1436999383 | 640 | 71,529.98 | 5.56 | 30 | 62,520 | 73.97 | 42.49 | -0.507 |
ESR2 | |||||||||
 1 | Normal | 530 | 59,216.33 | 8.81 | 30 | 63,590 | 83.34 | 55.32 | -0.288 |
 2 | rs1463893698 | 71 | 7738.54 | 5.28 | 30 | 8940 | 64.51 | 68.91 | -0.432 |
 3 | rs140630557 | 132 | 14,699.48 | 7.86 | 30 | 21,555 | 70.83 | 66.53 | -0.595 |
 4 | rs1450198518 | 530 | 59,232.33 | 8.81 | 30 | 63,590 | 83.15 | 55.32 | -0.293 |
 5 | rs754945292 | 530 | 59,218.30 | 8.81 | 30 | 63,590 | 82.96 | 54.79 | -0.297 |
 6 | rs1596423459 | 200 | 22,176.86 | 8.71 | 30 | 33,390 | 59.95 | 63.83 | -0.595 |
 7 | rs766843910 | 236 | 26,452.90 | 9.21 | 30 | 36,745 | 58.64 | 65.47 | -0.644 |
 8 | rs1596405923 | 338 | 37,655.09 | 9.24 | 30 | 58,995 | 68.40 | 61.82 | -0.462 |
 9 | rs762454979 | 338 | 37,877.39 | 9.20 | 30 | 53,370 | 71.83 | 59.52 | -0.445 |
 10 | rs1384121511 | 346 | 38,859.68 | 9.02 | 30 | 53,370 | 73.27 | 60.37 | -0.394 |
 11 | rs1249242790 | 530 | 59,216.28 | 8.81 | 30 | 63,590 | 82.42 | 56.15 | -0.303 |
 12 | rs1414263985 | 530 | 59,231.39 | 8.91 | 30 | 63,590 | 83.15 | 55.32 | -0.293 |
 13 | rs78255744 | 530 | 59,278.40 | 8.81 | 30 | 63,590 | 82.96 | 54.15 | -0.290 |
 14 | rs768924970 | 530 | 59,148.27 | 8.84 | 30 | 63,715 | 82.23 | 56.13 | -0.295 |
 15 | rs1257844897 | 478 | 53,614.00 | 8.94 | 30 | 67,475 | 84.46 | 53.59 | -0.231 |
 16 | rs200502775 | 524 | 58,533.64 | 8.81 | 30 | 63,590 | 84.29 | 53.95 | -0.260 |