Table 4 Effect of SNPs on stability of mutated protein predicted using I-Mutant
Case # | Docking score | Confidence score | Ligand RMSD (Ã…) |
|---|---|---|---|
ESR1 | |||
 Normal | -321.57 | 0.9687 | 59.59 |
 Case 1 | -312.34 | 0.9626 | 51.40 |
 Case 2 | -250.57 | 0.8820 | 68.86 |
 Case 3 | -227.19 | 0.8240 | 48.47 |
 Case 4 | -304.62 | 0.9566 | 52.44 |
 Case 5 | -292.53 | 0.9453 | 54.47 |
 Case 6 | -263.81 | 0.9069 | 62.42 |
 Case 7 | -277.91 | 0.9281 | 59.18 |
 Case 8 | -242.20 | 0.8634 | 56.26 |
 Case 9 | -164.97 | 0.5743 | 68.52 |
 Case 10 | -260.94 | 0.9019 | 58.70 |
 Case 11 | -228.87 | 0.8288 | 277.52 |
 Case 12 | -260.94 | 0.9019 | 58.70 |
 Case 13 | -244.96 | 0.8698 | 69.04 |
 Case 14 | -285.93 | 0.9381 | 57.60 |
 Case 15 | -307.44 | 0.9589 | 59.40 |
ESR2 | |||
 Normal | -275.18 | 0.9244 | 74.26 |
 Case 1 | -186.57 | 0.6751 | 56.00 |
 Case 2 | -173.23 | 0.6141 | 47.43 |
 Case 3 | -275.18 | 0.9244 | 74.28 |
 Case 4 | -273.60 | 0.9222 | 53.76 |
 Case 5 | -252.81 | 0.8866 | 44.89 |
 Case 6 | -260.64 | 0.9014 | 55.11 |
 Case 7 | -264.65 | 0.9083 | 24.63 |
 Case 8 | -259.86 | 0.9000 | 79.69 |
 Case 9 | -267.52 | 0.9130 | 24.85 |
 Case 10 | -260.94 | 0.9019 | 58.70 |
 Case 11 | -276.33 | 0.9260 | 53.74 |
 Case 12 | -270.34 | 0.9173 | 74.17 |
 Case 13 | -275.73 | 0.9252 | 53.97 |
 Case 14 | -292.51 | 0.9453 | 44.92 |
 Case 15 | -275.18 | 0.9244 | 74.26 |