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Table 2 General information on patients in each subgroup of the benign and non-benign groups

From: Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a

Item

Benign group

Non-benign group

F

P

Endometriosis cysts

Cystadenoma

Mature teratoma

Other neoplasms

F1

P1

BOTs

OC

Z

P2

Age

33.92 ± 7.94

35.12 ± 13.78

30.00 ± 9.87

42.83 ± 12.76

10.144

< 0.001

32.90 ± 11.56

45.85 ± 8.938

14.183

0.011

13.036

< 0.001

Exosome

OCS

0.271 ± 0.196

0.199 ± 0.181

0.188 ± 0.118

0.226 ± 0.199

2.594

0.054

0.521 ± 0.220

0.674 ± 0.296

1.51

0.12

32.057

< 0.001

CA125(U/mL)

10.99 ± 13.31

13.82 ± 41.66

3.43 ± 2.89

9.03 ± 18.99

1.920

0.128

32.65 ± 57.97

118.04 ± 116.81

2.219

0.026

27.888

< 0.001

HE4(pmol/L)

1.87 ± 0.81

1.86 ± 0.63

1.94 ± 0.66

1.94 ± 0.86

0.129

0.943

3.71 ± 1.84

12.20 ± 22.35

2.191

0.624

8.395

< 0.001

C5a(ng/ml)

4.73 ± 2.66

3.98 ± 1.48

4.62 ± 2.04

4.13 ± 1.79

1.267

0.287

5.85 ± 3.24

7.13 ± 3.15

1.119

0.11

8.136

< 0.001

ROMAindex

9.26 ± 5.64

10.82 ± 8.34

7.51 ± 4.29

9.26 ± 6.01

2.093

0.103

17.43 ± 9.71

44.52 ± 36.84

3.857

0.13

31.816

< 0.001

Serum

CA125(U/mL)

75.25 ± 83.00

36.79 ± 77.08

18.67 ± 12.71

32.75 ± 52.25

8.386

< 0.001

115.99 ± 149.92

260.34 ± 249.63

1.730

0.134

21.560

< 0.001

HE4(pmol/L)

51.35 ± 9.75

52.94 ± 17.90

47.11 ± 10.22

49.57 ± 12.58

1.840

0.141

63.13 ± 21.49

248.77 ± 335.30

1.735

0.005

13.897

< 0.001

  1. BOTs indicates Borderline Ovarian Tumors group; OC indicates Ovarian Cancer group;