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Table 4 Diagnostic efficacy of various indicators on ovarian cancer

From: Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a

Item

SE(%)

SP(%)

PPV(%)

NPV(%)

Accuracy(%)

Youden index(%)

Serum

CA125(U/mL)

75

66.8

34.4

92.0

70.9

41.8

 

HE4(pmol/L)

63.6

95.8

77.8

91.9

79.7

59.4

 

Premenopausal

57.1

95.3

66.7

93.1

76.2

52.4

 

Postmenopausal

73.3

100

100

83.3

86.65

73.3

Serum sEVs

OCS

77.3

93.2

72.3

90.9

85.25

70.5

CA125(U/mL)

61.4

96.3

75

91.4

78.85

57.7

HE4(pmol/L)

77.3

73.7

40,5

93.3

75.5

51

C5a(ng/ml)

68.2

77.9

41.7

91.4

73.05

46.1

ROMA

63.6

81.1

43.8

90.6

72.35

44.7

Premenopausal

60.7

80.6

34.0

92.6

70.65

41.3

Postmenopausal

66.7

85

76.9

77.3

75.85

51.7