Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a

Table 5 ROC curve analysis of ovarian malignancy in the diagnosis of various indicators

Item		AUC	Standard error	Cutoff	P	95%CI
Item		AUC	Standard error	Cutoff	P	Lower limit	Upper limit
Serum	CA125(U/mL)	0.768	0.047	46.360	< 0.0001	0.675	0.860
	HE4(pmol/L)	0.817	0.04	68.895	< 0.0001	0.725	0.908
	Premenopausal	0.820	0.0567	56.965	< 0.0001	0.760	0.871
	Postmenopausal	0.777	0.102	119.300	< 0.0001	0.604	0.899
Serum sEVs	OCS	0.871	0.037	0.497	< 0.0001	0.799	0.943
	CA125(U/mL)	0.839	0.039	34.605	< 0.0001	0.763	0.915
	HE4(pmol/L)	0.818	0.040	2.285	< 0.0001	0.740	0.896
	C5a(ng/ml)	0.744	0.046	5.695	< 0.0001	0.654	0.835
ROMA		0.815	0.045	16.980	< 0.0001	0.728	0.902
Premenopausal		0.763	0.061	10.440	< 0.0001	0.698	0.821
Postmenopausal		0.887	0.0619	19.500	< 0.0001	0.734	0.968

ISSN: 1757-2215