Table 2 Mendelian randomization estimates for the identified candidate metabolite associations with OC phenotypes

OC

4-acetamidobutanoate

IVW

43

0.026

1.78

1.07-2.95

0.772322416

WM

43

0.024

2.13

1.10-4.11

MR Egger

43

0.008

6.45

1.76-23.72

OC

alpha-hydroxyisovalerate

IVW

17

0.016

1.49

1.08-2.05

0.65956674

WM

17

0.035

1.60

1.03-2.48

MR Egger

17

0.254

1.76

0.69-4.46

OC

asparagine

IVW

46

0.024

0.65

0.45-0.95

0.772322416

WM

46

0.004

0.44

0.25-0.77

MR Egger

46

0.028

0.42

0.19-0.89

OC

3-(3-hydroxyphenyl) propionate

IVW

11

0.018

1.17

1.03-1.32

0.65956674

WM

11

0.040

1.20

1.01-1.44

MR Egger

11

0.428

1.16

0.82-1.63

OC

X-13183--stearamide

IVW

11

0.008

1.40

1.09-1.80

0.65956674

WM

11

0.025

1.49

1.05-2.12

MR Egger

11

0.158

1.49

0.90-2.48

MOC

1,5-anhydroglucitol (1,5-AG)

IVW

31

0.016

2.33

1.17-4.64

0.851594997

WM

31

0.023

3.21

1.18-8.77

MR Egger

31

0.052

5.77

1.06-31.43

MOC

ADpSGEGDFXAEGGGVR

IVW

7

0.005

2.52

1.33-4.77

0.851594997

WM

7

0.003

3.48

1.54-7.89

MR Egger

7

0.232

3.93

0.55-28.20

OCCC

betaine

IVW

24

0.033

0.21

0.05-0.88

0.981998335

WM

24

0.013

0.10

0.02-0.61

MR Egger

24

0.105

0.05

0.00-1.59

OCCC

estrone 3-sulfate

IVW

13

0.049

1.32

1.00-1.75

0.981998335

WM

13

0.014

1.59

1.10-2.29

MR Egger

13

0.408

1.21

0.78-1.88

OCED

3-(3-hydroxyphenyl) propionate

IVW

11

0.003

1.52

1.16-2.00

0.693730355

WM

11

0.005

1.70

1.17-2.46

MR Egger

11

0.045

2.34

1.14-4.77

OCED

1,5-anhydroglucitol (1,5-AG)

IVW

31

0.011

2.35

1.22-4.53

0.693730355

WM

31

0.030

2.65

1.10-6.40

MR Egger

31

0.406

2.00

0.40-10.07

OCED

arachidonate (20:4n6)

IVW

20

0.033

0.38

0.16-0.92

0.748839011

WM

20

0.007

0.20

0.06-0.64

MR Egger

20

0.031

0.17

0.04-0.75

OCED

1-linoleoylglycerophosphoethanolamine

IVW

11

0.014

2.98

1.24-7.13

0.693730355

WM

11

0.025

4.18

1.19-14.66

MR Egger

11

0.181

5.56

0.55-56.35

OCED

stearidonate (18:4n3)

IVW

11

0.023

0.36

0.15-0.87

0.694101869

WM

11

0.039

0.30

0.09-0.94

MR Egger

11

0.098

0.10

0.01-1.15

OCED

ADpSGEGDFXAEGGGVR

IVW

7

0.040

2.35

1.04-5.29

0.748839011

WM

7

0.009

2.94

1.30-6.62

MR Egger

7

0.023

19.77

3.22-121.42

SOC

X-13183--stearamide

IVW

11

0.008

1.48

1.11-1.97

0.871510468

WM

11

0.026

1.58

1.06-2.37

MR Egger

11

0.150

1.61

0.89-2.90

SOC

DSGEGDFXAEGGGVR

IVW

13

0.023

0.73

0.56-0.96

0.952113534

WM

13

0.024

0.65

0.44-0.94

MR Egger

13

0.092

0.47

0.21-1.05

SOC

2-hydroxyhippurate (salicylurate)

IVW

13

0.028

0.93

0.87-0.99

0.952113534

WM

13

0.035

0.90

0.82-0.99

MR Egger

13

0.184

0.91

0.80-1.04