Table 3 The results of heterogeneity testing and pleiotropy testing for candidate blood metabolites and several OC phenotypes
Outcome | Exposure | Nsnp | Heterogeneity Q | Pval | Pleiotropy intercept | Pval |
|---|---|---|---|---|---|---|
MOC | ADpSGEGDFXAEGGGVR | 7 | 5.416 | 0.49 | -0.021 | 0.66 |
MOC | 1,5-anhydroglucitol (1,5-AG) | 31 | 29.820 | 0.47 | -0.018 | 0.26 |
OC | X-13183--stearamide | 11 | 7.638 | 0.66 | -0.004 | 0.79 |
OC | alpha-hydroxyisovalerate | 17 | 10.200 | 0.86 | -0.005 | 0.71 |
OC | 3-(3-hydroxyphenyl)propionate | 11 | 9.816 | 0.46 | 0.001 | 0.96 |
OC | asparagine | 46 | 45.809 | 0.44 | 0.006 | 0.19 |
OC | 4-acetamidobutanoate | 43 | 56.405 | 0.07 | -0.015 | 0.06 |
OCCC | betaine | 24 | 28.526 | 0.20 | 0.024 | 0.39 |
OCCC | estrone 3-sulfate | 13 | 14.069 | 0.30 | 0.015 | 0.61 |
OCED | 3-(3-hydroxyphenyl)propionate | 11 | 4.949 | 0.89 | -0.036 | 0.23 |
OCED | 1,5-anhydroglucitol (1,5-AG) | 31 | 17.186 | 0.97 | 0.003 | 0.83 |
OCED | 1-linoleoylglycerophosphoethanolamine | 11 | 10.410 | 0.41 | -0.017 | 0.58 |
OCED | stearidonate (18:4n3) | 11 | 13.599 | 0.19 | 0.038 | 0.30 |
OCED | arachidonate (20:4n6) | 20 | 19.316 | 0.44 | 0.018 | 0.20 |
OCED | ADpSGEGDFXAEGGGVR | 7 | 10.734 | 0.10 | -0.102 | 0.06 |
SOC | X-13183--stearamide | 11 | 9.275 | 0.51 | -0.005 | 0.76 |
SOC | DSGEGDFXAEGGGVR | 13 | 8.823 | 0.72 | 0.020 | 0.27 |
SOC | 2-hydroxyhippurate (salicylurate) | 13 | 7.945 | 0.79 | 0.004 | 0.77 |