Table 4 The reverse Mendelian randomization analysis results: causal relationships between several OC phenotypes and candidate blood metabolites

Amino acid

4-acetamidobutanoate

OC

IVW

6

1.00 (0.98-1.02)

0.932

WM

6

1.00 (0.98-1.02)

0.878

MR Egger

6

1.01 (0.96-1.06)

0.710

alpha-hydroxyisovalerate

OC

IVW

6

1.00 (0.97-1.04)

0.931

WM

6

1.01 (0.97-1.05)

0.565

MR Egger

6

1.05 (0.96-1.14)

0.366

asparagine

OC

IVW

6

1.01 (0.99-1.02)

0.550

WM

6

1.00 (0.98-1.03)

0.662

MR Egger

6

1.00 (0.96-1.05)

0.919

betaine

OCCC

Wald ratio

1

1.00 (0.97-1.03)

0.937

3-(3-hydroxyphenyl)propionate

SOC

IVW

10

0.97 (0.90-1.04)

0.420

WM

10

0.99 (0.90-1.10)

0.861

MR Egger

10

0.95 (0.69-1.32)

0.784

Carbohydrate

1,5-anhydroglucitol (1,5-AG)

MOC

IVW

3

0.99 (0.98-1.00)

0.153

WM

3

0.99 (0.97-1.01)

0.210

MR Egger

3

1.04 (0.74-1.46)

0.851

1,5-anhydroglucitol (1,5-AG)

OCED

IVW

2

0.99 (0.96-1.02)

0.496

Lipid

estrone 3-sulfate

OCCC

Wald ratio

1

0.97 (0.82-1.14)

0.722

arachidonate (20:4n6)

OCED

IVW

2

0.99 (0.93-1.05)

0.739

1-linoleoylglycerophosphoethanolamine

OCED

IVW

2

1.00 (0.96-1.04)

0.964

stearidonate (18:4n3)

OCED

IVW

2

1.01 (0.97-1.05)

0.670

X-13183--stearamide

SOC

IVW

7

0.99 (0.94-1.03)

0.561

WM

7

0.98 (0.92-1.04)

0.458

MR Egger

7

0.89 (0.72-1.09)

0.311

Peptide

ADpSGEGDFXAEGGGVR

OCED

IVW

2

0.95 (0.89-1.01)

0.121

DSGEGDFXAEGGGVR

SOC

IVW

7

1.01 (0.96-1.06)

0.807

WM

7

1.00 (0.94-1.07)

0.911

MR Egger

7

0.88 (0.70-1.10)

0.323

ADpSGEGDFXAEGGGVR

MOC

IVW

3

1.02 (0.97-1.07)

0.469

WM

3

0.99 (0.95-1.04)

0.758

MR Egger

3

0.52 (0.23-1.19)

0.367

Xenobiotics

2-hydroxyhippurate (salicylurate)

SOC

IVW

7

0.99 (0.85-1.17)

0.938

WM

7

0.91 (0.74-1.13)

0.412

MR Egger

7

1.07 (0.51-2.23)

0.865