Fig. 2

Assessment of fertility. (A) Body weights of 3-, 8-, and 12-month-old female mice (n = 6 mice for each group). (B) Mean litter sizes in 6- and 8-month WT, Sesn1^−/−, Sesn2^−/−, and Sesn3^−/− mice (n = 6 mice for each group). (C) Serum AMH levels of 8-month (8 M) and 12-month (12 M) WT, Sesn1^−/−, Sesn2^−/−, and Sesn3^−/− mice (n = 6 mice for each group). (D) Representative estrous cycles from 8 M WT, Sesn1^−/−, Sesn2^−/−, and Sesn3^−/− mice (n = 6 mice for each group). M, metestrus; D, diestrus; P, proestrus; E, estrus. (E) Length of estrous cycles (n = 6 mice for each group). Results are expressed as the mean ± SEM. Statistical differences between WT and knockout mice were measured by an unpaired Student’s t test