Table 1 Serum N-glycome composition in benign neoplasm and ovarian cancer with different stages. Only the main glycan features describing glycome composition are shown. False discovery rate was controlled using Bonferroni (Padj). Man, mannosylation; G, galactose; F, fucose; B, bisecting GlcNAc; S, sialic acid. SD, standard deviation; CI, confidence interval
Dependent variable | Benign | Early Stages | Late Stages | Benign vs Early Stages | Benign vs Late Stages | Early Stages vs Late Stages | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean (%) | SD (%) | Mean (%) | SD (%) | Mean (%) | SD (%) | 95% CI | Padj | 95% CI | Padj | 95% CI | Padj | |
Man | 2.98 | 0.64 | 2.95 | 0.77 | 3.08 | 0.79 | (-0.37, 0.43) | 1.00E+00 | (-0.43, 0.23) | 1.00E+00 | (-0.56, 0.29) | 1.00E+00 |
G0 | 2.94 | 0.82 | 2.96 | 1.01 | 3.41 | 0.99 | (-0.52, 0.49) | 1.00E+00 | (-0.89, -0.05) | 2.40E-02 | (-0.99, 0.09) | 1.38E-01 |
G1 | 4.38 | 0.74 | 4.07 | 1.02 | 4.42 | 1.18 | (-0.22, 0.84) | 4.68E-01 | (-0.47, 0.40) | 1.00E+00 | (-0.91, 0.22) | 4.18E-01 |
G2 | 3.35 | 0.69 | 3.08 | 0.90 | 3.25 | 1.48 | (-0.32, 0.85) | 8.25E-01 | (-0.39, 0.57) | 1.00E+00 | (-0.79, 0.45) | 1.00E+00 |
G total | 7.73 | 1.25 | 7.16 | 1.83 | 7.67 | 2.32 | (-0.41, 1.56) | 4.72E-01 | (-0.75, 0.87) | 1.00E+00 | (-1.57, 0.53) | 6.98E-01 |
F neutral | 1.32 | 0.16 | 6.27 | 1.70 | 6.48 | 1.68 | (-0.32, 1.37) | 3.95E-01 | (-0.38, 1.02) | 8.05E-01 | (-1.11, 0.69) | 1.00E+00 |
F sialo | 17.10 | 2.03 | 15.79 | 3.01 | 16.79 | 2.60 | (-0.04, 2.66) | 6.00E-02 | (-0.80, 1.43) | 1.00E+00 | (-2.44, 0.44) | 2.86E-01 |
F total | 23.90 | 3.00 | 22.06 | 4.44 | 23.27 | 3.68 | (-0.12, 3.80) | 7.40E-02 | (-0.99, 2.25) | 1.00E+00 | (-3.30, 0.89) | 4.96E-01 |
B neutral | 3.36 | 0.66 | 3.28 | 1.01 | 3.48 | 1.00 | (-0.39, 0.56) | 1.00E+00 | (-0.51, 0.27) | 1.00E+00 | (-0.71, 0.31) | 1.00E+00 |
B sialo | 8.35 | 1.46 | 7.52 | 1.59 | 7.79 | 1.54 | (-0.01, 1.68) | 5.20E-02 | (-0.13, 1.26) | 1.55E-01 | (-1.17, 0.63) | 1.00E+00 |
B total | 11.72 | 1.88 | 10.80 | 2.45 | 11.27 | 2.22 | (-0.25, 2.09) | 1.79E-01 | (-0.52, 1.41) | 8.03E-01 | (-1.73, 0.78) | 1.00E+00 |
S1 | 20.71 | 2.87 | 20.50 | 4.82 | 19.78 | 7.16 | (-2.57, 2.98) | 1.00E+00 | (-1.37, 3.22) | 9.92E-01 | (-2.25, 3.68) | 1.00E+00 |
S2 | 57.02 | 5.21 | 57.48 | 7.69 | 56.56 | 10.83 | (-4.85, 3.92) | 1.00E+00 | (-3.16, 4.09) | 1.00E+00 | (-3.76, 5.61) | 1.00E+00 |
S3 | 3.31 | 0.69 | 3.86 | 0.99 | 4.17 | 1.00 | (-1.03, -0.07) | 1.80E-02 | (-1.26, -0.47) | 1.17E-06 | (-0.83, 0.19) | 3.96E-01 |
S4 | 1.07 | 0.33 | 1.15 | 0.48 | 1.33 | 0.45 | (-0.30, 0.15) | 1.00E+00 | (-0.44, -0.07) | 3.00E-03 | (-0.42, 0.06) | 2.09E-01 |
S total | 82.11 | 3.51 | 82.99 | 4.35 | 81.84 | 4.69 | (-3.15, 1.39) | 1.00E+00 | (-1.61, 2.14) | 1.00E+00 | (-1.28, 3.57) | 7.61E-01 |