Table 2 Gene-burden analysis of POI-related genes
From: Oligogenic basis of premature ovarian insufficiency: an observational study
Gene | Patient | Control | P-value | Odds ratio (95% confidence interval) |
|---|---|---|---|---|
RAD52 | 9 (9.7%) | 8 (1.7%) | 5.28 × 10–4 | 6.12 (2.30–16.31) |
MSH6 | 11 (11.8%) | 13 (2.8%) | 5.98 × 10–4 | 4.66 (2.02–10.77) |
AR | 4 (4.3%) | 0 (0%) | 7.31 × 10–4 | Inf (Nan–Inf) |
TP63 | 4 (4.3%) | 1 (0.2%) | 3.18 × 10–3 | 20.85 (2.30–188.78) |
IGSF10 | 6 (6.5%) | 6 (1.3%) | 7.26 × 10–3 | 5.28 (1.66–16.74) |
POLG | 4 (4.3%) | 2 (0.4%) | 8.33 × 10–3 | 10.40 (1.88–57.67) |
TEP1 | 5 (5.4%) | 4 (0.9%) | 8.39 × 10–3 | 6.55 (1.72–34.87) |
MLH1 | 6 (6.5%) | 7 (1.5%) | 1.17 × 10–2 | 4.51 (1.48–13.75) |
ERCC6 | 4 (4.3%) | 3 (0.6%) | 1.70 × 10–2 | 6.92 (1.52–31.46) |
FANCG | 2 (2.2%) | 0 (0%) | 2.75 × 10–2 | Inf (Nan–Inf) |
MSH5 | 2 (2.2%) | 0 (0%) | 2.75 × 10–2 | Inf (Nan–Inf) |
GALT | 2 (2.2%) | 0 (0%) | 2.75 × 10–2 | Inf (Nan–Inf) |
GDF9 | 4 (4.3%) | 4 (0.9%) | 2.96 × 10–2 | 5.18 (1.27–21.10) |
FANCM | 3 (3.2%) | 2 (0.4%) | 3.48 × 10–2 | 7.75 (1.27–46.84) |
NUP107 | 3 (3.2%) | 2 (0.4%) | 3.48 × 10–2 | 7.75 (1.27–46.84) |