Oligogenic basis of premature ovarian insufficiency: an observational study

Table 3 Pathogenicity and Digenic Effect prediction

Sample ID	Gene	Alleles	VarCoPP			Digenic Effect
Sample ID	Gene	Alleles	Prediction score	Predicted class	Confidence zone	True digenic	Monogenic + modifier	Dual molecular diagnosis	Predicted class
64	RAD52	NC_000012.11 (NM_134424.4) c.1037 C > A	1.0	Disease-causing	99.9%	0.42	0.35	0.23	True digenic
64	MSH6	NC_000002.11 (NM_000179.3) c.4068_4071dupTTGA	1.0	Disease-causing	99.9%	0.42	0.35	0.23	True digenic
66	RAD52	NC_000012.11 (NM_134424.4) c.1037 C > A	1.0	Disease-causing	99.9%	0.34	0.44	0.22	Monogenic + modifier
66	MSH6	NC_000002.11 (NM_000179.3) c.3488 A > T	1.0	Disease-causing	99.9%	0.34	0.44	0.22	Monogenic + modifier

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