From: Oligogenic basis of premature ovarian insufficiency: an observational study
 | Patients with > 1 variant (n) | Odds ratio (95% confidence interval) | P-value | |
---|---|---|---|---|
POI | Controls | |||
Meiosis and DNA repair | 21 | 15 | 8.75 (4.31–17.76) | 4.04 × 10–9 |
Gonadal formation | 0 | 0 | / | 1 |
Ovarian development | 5 | 3 | 8.75 (2.05–37.28) | 0.004 |
Signaling molecules and transcription factors | 5 | 2 | 13.15 (2.51–68.87) | 0.001 |