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Table 3 The summary of similar studies

From: Controlled ovarian stimulation in cancer patients under 18 years old; a case series

Author; Year

Kutteh et al, 2018 [9]

Peddie et al, 2018 [16]

Lavery et al, 2016 [10]

Oktay et al, 2014 [14]

Reichman et al, 2012 [17]

Kim et al, 2011 [8]

Oktay et al, 2010 [15]

Noyes et al, 2009 [13]

Nagashima et al, 2005 [12]

Patients

3

2

1

1

8

7

6

5

4

3

2

1

5

4

3

2

1

1

1

1

1

2

1

Diagnosis

Medulloblastoma

myelodysplastic clonef

Sickle cell anemia

ALL

Germ cell tumor

Turner syndrome

  

Myelodysplastic syndrome

SPH caused by TGVd

Turner syndrome

Ovarian luteinized the coma

AML

17

Age (Menarche age)

14 (13)

16 (12)

14 (13)

14 (12)

18

18

17

16

16

16

15

14

14 (13)

15 (13)

14 (11)

13 (12)

13 (13)

13

17

14 (11)

19

18

No

Ovarian surgery

No

No

No

No

No

No

No

No

No

No

No

No

No

Left oophorectomy

No

No

No

No

No

No

Left oophorectomy

No

No

Radiotherapy

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

No

Yes

Chemotherapy

No

No

No

No

No

No

No

No

No

No

No

No

Yes

No

No

No

No

No

No

No

No

No

N/Aa

AMH (ng/mL)

12.5g

6.8g

13.3g

N/A

16e

N/A

24e

23.8e

N/A

N/A

N/A

N/A

0.8

1.6

0.9

0.76

1.59

0.95

N/A

0.9

N/A

N/A

N/A

FSH (mIU/mL)

N/A

N/A

N/A

7.1

2.9

7.6

4.2

7.6

4.3

1.2

4.8

2

7.8

5.6

5.3

5.6

5.7

5.0

N/A

5.3

N/A

N/A

N/A

LH (mIU/mL)

N/A

N/A

N/A

10.4

3.2

3.9

3.6

3.8

3.3

0.8

6.2

6.2

8.1

9.2

9.5

5.3

3.9

2.9

N/A

9.5

N/A

N/A

N/A

AFC

31

15

25

17

12

20

20

16

16

18

6

13

5

11

12

6

6

9

N/A

12

N/A

N/A

N/A

COS Protocol

GnRH-antagonist

GnRH-antagonist

GnRH-agonist

GnRH-antagonist

GnRH-antagonist

GnRH-agonist

GnRH-antagonist

GnRH-agonist

N/A

N/A

Duration of stimulation

10

12

11

N/A

12

10

11

10

10

11

10

14

12

11

10

10

11

N/A

N/A

N/A

N/A

N/A

N/A

Gonadotropins

HMG

HMG

r-FSH

r-FSH (+HMG or r-LH)

HMG

r-FSH (+HMG)

r-FSH (+HMG)

N/A

N/A

N/A

Starting gonadotropin dose (IU)

150

225

150

225

225

187.5

150

150

112.5

112.5

150

150

N/A

N/A

N/A

N/A

N/A

225

N/A

225 (+150)c

225 (+150)b

N/A

N/A

N/A

Total gonadotropin dose (IU)

1800

1800

1950

N/A

3075

1875

3350

1500

1462.5

1312.5

1875

2625

1775

2137.5

2075

2250

2625

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Triggering medication

GnRH-agonist

r-HCG

r-HCG

GnRH-agonist

r-HCG

GnRH-agonist

r-HCG

u-HCG

r-HCG

N/A

GnRH-agonist

N/A

N/A

N/A

Total oocytes retrieved

26

18

25

13

7

31

5

14

29

21

5

7

21

2

11

16

19

20

14

7

11

38

0

0

Total mature oocytes (MII)

17

12

23

12

1

30

3

11

25

16

4

7

10

4

8

7

9

8

8

4

8

N/A

0

0

OHSS

No

No

No

N/A

No

Yes

No

No

No

No

No

 

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

  1. aNot Available
  2. bThe first cycle
  3. cSecond cycle
  4. dSecondary pulmonary hypertension caused by transposition of great vessels
  5. epmol/L
  6. fMyelodysplastic/pre-malignant clone with monosomy 7
  7. gnmol/L