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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Bushenhuoluo Decoction improves polycystic ovary syndrome by regulating exosomal miR-30a-5p/ SOCS3/mTOR/NLRP3 signaling-mediated autophagy and pyroptosis

Fig. 2

BSHLD repressed autophagy and NLRP3-mediated pyroptosis in PCOS rats. A ELISA assay for the evaluation of IL-1β and IL-18 levels in ovarian tissues. B RT-qPCR analysis of NLRP3, ASC, and Caspase 1 mRNA levels. C-D Immunohistochemical staining examined the expression of NLRP3 and LC3B. E Western blotting analysis was performed for the quantification of ATG5, Beclin1, ULK1, LC3II/I, p-mTOR, mTOR, p-P70S6K, and P70S6K protein levels. Results are presented as mean ± SD. n = 10. * p < 0.05, ** p < 0.01, *** p < 0.001

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Journal of Ovarian Research

ISSN: 1757-2215

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