Fig. 4

Effects of miR-1290-overexpressing or -inhibited CAFs-derived conditioned medium on ovarian cancer cell aggressiveness SKOV3 and A2780 cells were cultured in CAFs transduced with miR-1290 mimics or inhibitor and examined for cell viability by MTT (A); DNA synthesis capacity by EdU (B); cell invasion by Transwell with chambers pre-coated with Matrigel (C); the protein levels of E-cadherin, vimentin, p-mTOR, mTOR, p-Akt, and Akt by Immunoblotting (D). **P < 0.01, compared with CAFs (NC mimics)-CM group; ##P < 0.01 compared with CAFs (NC inhibitor)-CM group