Fig. 5

The miR-1290/OGN axis in CAFs modulates ovarian cancer cell aggressiveness SKOV3 and A2780 cells were cultured in CAFs co-transduced with miR-1290 mimics and OGN-OE and examined for cell viability by MTT (A); DNA synthesis capacity by EdU (B); cell invasion by Transwell with chambers pre-coated with Matrigel (C); the protein levels of E-cadherin, vimentin, p-mTOR, mTOR, p-Akt, and Akt by Immunoblotting (D). **P < 0.01, compared with CAFs (NC + NC mimics)-CM group; ##P < 0.01 compared with CAFs (OGN-OE + miR-1290 mimics)-CM group