Fig. 4

Combination treatment improves the antitumor activity in vivo. A Flow chart of animal experiments. B In vivo imaging was used to monitor the spread of ID8-Luc cells in mice. C Bruker MI SE software was used to quantify fluorescence intensity emitted from ID8-luc cells. D The volume of ascites produced in each group was measured after the mice were sacrificed. Each group consisted of at least three mice in every experiment and two independent experiments were performed. E The body weight of mice was monitored every five days since the first administration. Statistical significance was represented as *p < 0.05, **p < 0.01 and ***p < 0.001 compared with the control group