Table 2 Information of 12-weeks post treatment and changes in endocrine and metabolic profile

Anthropometric characteristics

Body weight (kg)

57.00 ± 5.85

0.00 (-0.13 to 0.00)

58.56 ± 6.64 *

0.00 (-0.05 to 0.00)

0.7318

BMI (kg/m²)

21.63 (19.84–23.20)

0.00 (-0.05 to 0.00)

23.22 (19.71–23.76)

0.00 (-0.17 to 0.00)

0.8021

Gonadal hormones

AMH (ng/mL)

10.36 ± 4.14 *

-2.79 (-4.68 to -1.35)

9.60 ± 5.11*

-0.74 (-1.67 to -0.01)

0.0017

LH (mIU/mL)

15.68 (10.15–21.75)

-2.76 (-6.32 to 6.33)

10.20 (6.39–16.23) *

-4.22 (-16.33 to 0.25)

0.4186

FSH (mIU/mL)

7.37 ± 2.11

0.31 (-1.15 to 2.24)

5.51 ± 2.05

-0.94 (-3.01 to 0.38)

0.0677

LH/FSH

2.20 ± 1.18

-0.42 (-1.24 to 0.10)

2.11 ± 0.95

-0.16 (-1.91 to 0.64)

0.8069

TT (ng/mL)

0.63 (0.44–0.73) *

-0.15 ± 0.21

0.77 (0.60–0.86) *

-0.10 ± 0.18

0.4154

FAI (%)

4.21 (1.99–7.12) *

-3.41 ± 5.98

11.67 (6.41–15.86)

-1.16 ± 5.30

0.2597

SHBG (nmol/L)

53.70 (35.53–73.60) **

14.50 (-1.45 to 31.33)

25.40 (19.60–39.80)

1.60 (-5.85 to 5.30)

0.0150

AND (ng/mL)

3.51 ± 1.60 *

-1.79 (-2.79 to -0.42)

3.46 ± 1.89

-0.79 ± 1.12

0.321

DHEAS (ng/mL)

274.20 ± 115.70

-17.74 ± 59.78

288.70 ± 109.40

23.96 ± 52.03

0.1013

Glucose and lipid-related parameters

FPG (mmol/L)

5.21 (4.92–5.38)

-0.31 (-0.46 to 0.26)

5.25 (4.79–5.56)

-0.03 (-0.27 to 0.33)

0.3254

FINS (mU/L)

7.70 (4.90–9.30)

-1.38 ± 3.92

10.35 (5.95–14.75)

-0.71 ± 4.40

0.699

HOMA-IR

1.66 (1.16–2.16)

-0.47 ± 1.08

2.44 (1.24–3.62)

-0.20 ± 1.23

0.5762

AUCIns (mU/L*min)

5436 (3981–6612)

-1556 (-4410 to 500.3)

12,633 (7049–18,530)

780 (-4401 to 4317)

0.1693

AUCGlu (mmol/L*min)

1167 (839.6–1343)

-56.90 ± 236.20

1249 (1139–1515)

98.11 ± 330.90

0.2071

AUCIns/AUCGlu

5.12 ± 1.54

-1.80 ± 3.51

10.49 ± 4.97

-0.71 ± 3.44

0.4605