Fig. 6

FABP5 accelerates the proliferation of KGN cells by activating PI3K-AKT signaling. A Immunoblotting plot showing the expression of FABP5 and AKT and the phosphorylation of AKT in KGN cells after 48 h of FABP5 overexpression or knockdown. B, C Line chart showing the proliferation of KGN cells treated with 10 μM LY294002 or SC79 after 48 h of FABP5 overexpression or knockdown, as determined by CCK8 assays. * represents the comparison between the EV-ctrl and myc-FABP5 or siNC and siFABP5 groups; # represents the comparison between the myc-FABP5 and myc-FABP5 + LY294002 or siFABP5 and siFABP5 + SC79 groups; D, F Immunofluorescence staining of Ki67 in KGN cells treated with 10 μM LY294002 or SC79 for 48 h after FABP5 was overexpressed or knocked down. Scale bar, 100 μm. E, G Statistical analysis of Ki67-positive cells. Five fields of view were randomly selected. *P < 0.05, **P < 0.01, ***P < 0.001. ##P < 0.01, ###P < 0.01