Table 1 Basic information of the included studies
Study (year) | Natural product (type active ingredient study) | Species (age model group (n)/ treatment group (n) weight) | Experimental model method | Natural product intervention (dose duration route) | Outcomes | Potential mechanisms |
|---|---|---|---|---|---|---|
Mobasher et al. 2023 [30] | Plant, phytochemicals polyphenol, resveratrol
| Wistar rats (12–16 weeks, 7/7, 200–240 g) | Intraperitoneal injection daily of Cy for 15 days (200 mg/kg + 8 mg/kg/d) | 10 mg/kg/d, 3 weeks, via p.o | (8), (9), (10), (11), (13), (14), (16), (23) | Role of iNOS/Caspase-3 Pathway |
Luo et al. 2023 [31] | Marine species marine chemicals peptides, sea cucumber peptide | ICR mouse (8–10 weeks, 3–8/3–8, 30 ± 2 g) | A combined intraperitoneal injection of Cy and BU for 1 day (40 mg/ml + 2.4 mg/ml) | 0.6 mg/g/d, 5 weeks, via gavage | (6), (7), (8), (9), (11), (12), (20), (21), (22) | Upregulation the expression of Mapk1, Esr1, Gnrh, StAR, Fshr, and Cyp19a1 due to the activation of the cAMP-related signaling pathways |
Moradi et al. 2023 [32] | Plant, phytochemicals alkaloid, capsaicin
| Wistar rats (12–16 weeks, 6/6, 210 ± 10 g) | Intraperitoneal injection daily of Cy for 4 days (200 mg/kg + 8 mg/kg/d) | 0.5 mg/kg/d, 2 weeks, via i.p | (2), (4), (6), (7), (10), (11), (20), (21) | Upregulation the expression of BAX gene and decrease the expression of apoptosis inducing genes (BCL-2 and P53). |
Moradi et al. 2023 [32] | Plant, phytochemicals Flavonol, quercetin
| Wistar rats (12–16 weeks, 6/6, 210 ± 10 g) | Intraperitoneal injection daily of Cy for 4 days (200 mg/kg + 8 mg/kg/d) | 100 mg/kg/d, 2 weeks, via i.p | (2), (4), (6), (7), (10), (11), (20), (21) | Upregulation the expression of BAX gene and decrease the expression of apoptosis inducing genes (BCL-2 and P53). |
Ä°lgen et al. 2023 [33] | Plant, phytochemicals quaternary ammonium salt of an isoquinoline alkaloid, berberine
| Wistar rats (not mention, 7/7, 180–220 g) | Intraperitoneal injection daily of Cy for 15 days (50 mg/kg + 8 mg/kg/d) | 200 mg/kg/d, 2 weeks, via gavage | (1), (2), (3), (23), (24), (25) | Protective and/or therapeutic effects of reduction proinflammatory cytokines (TNF-α, IL-1, and IL-6) |
Xin et al. 2023 [34] | Plant, phytochemicals biphenyls, honokiol
| C57BL/6 mice (7 weeks, 5/5, 16–19 g) | A single dose of whole-body gamma radiation (3.2 Gy, XCELL 160) with a dose rate of 0.4975 Gy/min | 10 mg/kg/d, 1 week, via i.p | (1), (4), (5), (6), (7), (13), (18), (19), (20), (21), (22), (24) | Inhibition apoptosis and pyroptosis by enhancing HO-1 and Nrf2 expression and nucleus translocation |
Wang et al. 2023 [35] | Plant, phytochemicals imidazolidine-2,4-dione, allantoin
| Sprague-Dawley rats (not mention, 3–10/3–10, 180–220 g) | Intraperitoneal injection daily of Cy for 21 days (75 mg/kg/d) | 140 mg/kg/d, 3 weeks, not mention | (7), (8), (9), (20), (21), (24) | Attenuation of the apoptosis, autophagy, and pyroptosis |
Zhang et al. 2022 [36] | Plant, phytochemicals coumarine, daphnetin
| C57BL/6 mice (6–8 weeks, 5/5, not mention) | Subcutaneous injection daily of D-gal for 42 days (600 mg/kg/d) | 30 mg/kg/d, 6 weeks, via i.p | (1), (2), (3), (4), (5), (7), (8), (14), (16), (18), (19) | Activation of the antioxidant and anti-senescent signaling pathways |
Li et al. 2022 [37] | Plant, phytochemicals flavone, chrysin
| C57BL/6 mice (7–8 weeks, 20/20, not mention) | Subcutaneous injection daily of D-gal for 42 days (200 mg/kg/d) | 144.4 mg/kg/d, not mention, not mention | (2), (3), (4), (6), (7), (8), (10), (11), (13), (14), (17), (20), (21), (22), (23), (24), (25) | Reduction of inflammation and oxidative stress; inhibition of cell apoptosis |
Zhao et al. 2022 [38] | Marine species marine chemicals peptides, tilapia skin peptides | C57BL/6 mice (7–8 weeks, 3–15/3–15, not mention) | Intraperitoneal injection daily of Cy for 14 days (10 mg/kg/d) | 1000 mg/kg/d, 4 weeks, via gavage | (1), (2), (3), (4), (5), (7), (8), (9), (10), (11), (12), (13), (14), (18), (19), (20), (21), (22) | Inhibition of oxidative stress; regulation Bcl-2/Bax/caspase-3 apoptosis pathway; enhancement of the Nrf2/HO-1 signaling pathway |
Wu et al. 2022 [3] | Plant, phytochemicals quaternary ammonium salt of an isoquinoline alkaloid, berberine
| Sprague–Dawley rats (not mention, 6/6, 250 g) | Intraperitoneal injection daily of Cy for 15 days (50 mg/kg + 8 mg/kg/d) | 400 mg/kg/d, 4 weeks, via gavage | (6), (7), (8), (9), (12) | Inhibition of the PTEN/AKT1/FoxO1 signaling pathway |
Barberino et al. 2022 [39] | Plant, phytochemicals flavane, EGCG
| Swiss mice (8 weeks, 5/5, 30–35 g) | Intraperitoneal injection singly of Cy for 1 day (200 mg/kg) | 50 mg/kg/d, 3 days, via i.p | (1), (2), (5), (16) | Suppression of inflammation and apoptosis; regulation of the Akt/FOXO3a/rpS6 signaling pathway |
Zheng et al. 2022 [40] | Plant, phytochemicals Flavonol, quercetin
| Sprague-Dawley rats (12 weeks, 15/15, 260 ± 20 g) | Intraperitoneal injection singly of Cy for 1 day (100 mg/kg) | 100 mg/kg/d, 6 weeks, via gavage | (1), (2), (3), (4), (5), (6), (7), (8), (9), (12), (13), (14), (15), (17) | Inhibition of oxidative stress level and regulation of the PI3K/Akt/FoxO3a signalling pathway |
Ibrahim et al. 2021 [41] | Plant, phytochemicals polyphenol, resveratrol
| Wistar rats (12–14 weeks, 8/8, 180–200 g) | Intraperitoneal injection singly of CDDP for 1 day (7 mg/kg) | 10 mg/kg/d, 4 weeks, via gavage | (7), (8), (10), (13), (14), (15), (16), (23), (24), (25) | Attenuation of oxidative stress, inflammation and apoptosis |
Chen et al. 2021 [42] | Plant, phytochemicals isoflavone, puerarin
| Kunming mice (8 weeks, 10/10, 25–30 g) | A combined intraperitoneal injection of Cy and BU for 1 day (120 mg/kg + 30 mg/kg) | 200 mg/kg/d, 4 weeks, via gavage | (1), (2), (3), (4), (5), (18), (20), (21) | Involvement of the Wnt/β-catenin signaling pathway, as well as relief of oxidative stress |
Jiang et al. 2019 [43] | Plant, phytochemicals polyphenol, resveratrol
| Kunming mice (6 weeks, 6/6, not mention) | A combined intraperitoneal injection of Cy and BU for 1 day (120 mg/kg + 30 mg/kg) | 40 mg/kg/d, 4 weeks, via gavage | (1), (2), (3), (4), (5), (11), (12), (13), (14), (15), (23), (25) | Relief of oxidative stress and inflammation; involvement of the Hh signaling pathway |
Li et al. 2020 [44] | Marine species marine chemicals peptides, oyster polypeptides | C57BL/6 mice (7–8 weeks, 6–10/6–10, 18–22 g) | Subcutaneous injection daily of D-gal for 42 days (200 mg/kg/d) | 1000 mg/kg/d, 6 weeks, via gavage | (1), (2), (3), (4), (5), (6), (8), (9), (10), (13), (14), (22) | Rescue of ovarian oxidative damage; reduction of apoptosis |
Delkhosh et al. 2019 [45] | Coenzyme in vivo chemicals benzoquinone coenzyme Q10
| NMRI mice (8–10 weeks, 8/8, 20–25 g) | Intraperitoneal injection daily of Cy for 21 days (20 mg/kg/d) | 22 mg/kg every other day, 3 weeks, via i.p | (1), (2), (4) | Exertion the antioxidant and proliferative properties |
Mahran et al. 2019 [46] | Plant, phytochemicals monoterpenoid, carvacrol
| Wister rats (23 days, 5–6/5–6, not mention) | A single dose of whole-body gamma radiation (3.2 Gy, LD20) with a doserate of 0.48 Gy/min | 80 mg/kg/d, 5 days, via i.p | (6), (7), (8), (12), (23) | Counteraction of oxidative stress and dysregulation of the cross-talk between IGF-1 and TNF-α |
Mahran et al. 2019 [46] | Plant, phytochemicals monoterpenoid, thymol
| Wister rats (23 days, 5–6/5–6, not mention) | A single dose of whole-body gamma radiation (3.2 Gy, LD20) with a dose rate of 0.48 Gy/min | 80 mg/kg/d, 5 days, via i.p | (6), (7), (8), (12), (23) | Counteraction of oxidative stress and dysregulation of the cross-talk between IGF-1 and TNF-α |
Li et al. 2019 [47] | Plant, phytochemicals glycosyloxyflavone icariin
| C57BL/6 mice (not mention, 10/10, not mention) | Subcutaneous injection daily of D-gal for 42Â days (200Â mg/kg/d) | 100Â mg/kg/d, 6Â weeks, via i.p | (1), (2), (3), (4), (5), (6), (7), (8), (9) | Promotion of DNA damage repair and attenuation ovarian injury |
Mantawy et al. 2019 [27] | Plant, phytochemicals flavone, chrysin
| Sprague–Dawley rats (3 weeks, 5–12/5–12, 40–50 g) | A single dose of whole-body gamma-radiation (3.2 Gy, LD20) with a dose rate of 0.48 Gy/min | 50 mg/kg/d, 17 days, via p.o | (1), (4), (5), (7), (12), (23) | Downregulation of the TGF-β/MAPK signaling pathway and hinder of inflammatory and apoptotic signal transduction pathways |
Yan et al. 2018Â [48] | Plant, phytochemicals polyphenol, curcumin
| C57BL/6 mice (7–8 weeks, 8–10/8–10, not mention) | Subcutaneous injection daily of D-gal for 42 days (200 mg/kg/d) | 100 mg/kg/d, 6 weeks, via i.p | (1), (2), (3), (4), (5), (7), (8), (9), (10), (13), (14), (18), (19), (22) | Inhibition of oxidative stress and apoptosis; regulation of the Nrf2/HO-1 and the PI3K/Akt signaling pathways |
Melekoglu et al. 2018 [49] | Plant, phytochemicals polyphenol, curcumin
| Wister rats (3–4 months, 10/10, not mention) | Intraperitoneal injection daily of Cy for 15 days (200 mg/kg + 8 mg/kg/d) | 100 mg/kg/d, 2 weeks, not mention | (6), (7), (8), (9), (13), (14), (15), (16) | Improvement of oxidative stress marker levels and ovarian reserve marker levels |
Melekoglu et al. 2018 [49] | Plant, phytochemicals polyphenol, capsaicin
| Wister rats (3–4 months, 10/10, not mention) | Intraperitoneal injection daily of Cy for 15 days (200 mg/kg + 8 mg/kg/d) | 0.5 mg/kg/d, 2 weeks, not mention | (6), (7), (8), (9), (13), (14), (15), (16) | Improvement of oxidative stress marker levels and ovarian reserve marker levels |
Wu et al. 2018 [50] | Plant, phytochemicals polysaccharides, dendrobium officinal polysaccharides | Kunming mice (15 months, 6–14/6–14, not mention) | NA | 70 mg/kg/d, 10 weeks, via p.o | (7), (11), (12), (13), (14), (17), (22), (23), (25) | Reduction of pro-inflammatory cytokines and oxidative stress levels; inhibition of the NF-κB/p53/Bcl-2 mediate signaling pathways; protection and increase of the numbers of mitochondria and endoplasmic reticulum |
He et al. 2017 [51] | Plant, phytochemicals Steroid glycosides and triterpene saponins, ginsenoside Rg1
| C57BL/6 mice (3Â months, 25/25, not mention) | Subcutaneous injection daily of D-gal for 42Â days (200Â mg/kg/d) | 20Â mg/kg/d, 4Â weeks, via s.c | (1), (3), (4), (6), (7), (8), (11), (13), (14), (17), (23), (24), (25) | Enhancement of the anti-inflammatory and antioxidant capacities; reduction of the expression of senescence signal pathway proteins |
Soliman Said et al. 2016 [52] | Plant, phytochemicals polyphenol, resveratrol
| Sprague–Dawley rats (23 days, 6–12/6–12, 30–40 g) | A single dose of whole-body gamma-radiation (3.2 Gy, LD20) with a dose rate of 0.48 Gy/min | 25 mg/kg/d, 17 days, via p.o | (1), (4), (5), (6), (11), (12) | Inhibition of NF-κB provoked inflammatory cytokines and diminishment of the ovarian inflammation; upregulation of the PPAR-γ and SIRT1 expression |
