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Table 2 Univariate and multivariate analysis of the factors correlated with progression - free survival (PFS) of ovarian cancer patients

From: Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway

Variables

Univariate analysis

 

Multivariate analysis

HR

95%CI

p value

 

HR

95%CI

p value

Age (≥ 60)

1.74

1.20–2.54

< 0.01

 

0.74

0.49–1.13

0.16

Tumor size

       

< 5 cm

1

   

1

  

5-10 cm

0.72

0.49–1.08

0.11

    

>10 cm

0.44

0.30–0.65

< 0.01

 

2.05

1.33–3.17

< 0.01

Histology

       

serous carcinomas

1

   

1

  

mucinous carcinoma

0.76

0.43–1.31

0.32

    

endometrioid carcinoma

0.63

0.34–1.18

0.15

    

others

0.33

0.13–0.80

0.02

 

0.58

0.23–1.53

0.28

Grade

       

G1

1

   

1

  

G2

1.47

0.96–2.27

0.08

    

G3

1.52

1.06–2.19

0.02

 

0.77

0.50–1.18

0.22

G4

4.74

2.31–9.73

< 0.01

 

1.87

0.74–4.70

0.19

FIGO stage

       

I

1

   

1

  

II

3.98

2.34–6.76

< 0.01

 

3.89

0.51–29.59

0.19

III

1.91

1.33–2.73

< 0.01

 

19.69

2.65-146.25

< 0.01

IV

4.10

2.65–6.32

< 0.01

 

38.21

4.83-301.96

< 0.01

TGFBIp expression

3.72

2.44–5.68

< 0.01

 

3.13

1.97–4.99

< 0.01

Ki67 expression

1.52

1.00-2.30

0.04

 

0.90

0.57–1.43

0.65

EGFR expression

0.81

0.57–1.15

0.23

    

PDL1 expression

1.20

0.83–1.71

0.34