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Table 3 Univariate and multivariate analysis of the factors correlated with overall survival (OS) of ovarian cancer patients

From: Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway

Variables

Univariate analysis

 

Multivariate analysis

HR

95%CI

p value

 

HR

95%CI

p value

Age (≥ 60)

0.58

0.37–0.90

0.01

 

0.78

0.49–1.25

0.30

Tumor size

       

< 5 cm

1

   

1

  

5-10 cm

0.48

0.28–0.83

< 0.01

 

2.91

1.15–6.74

0.04

>10 cm

4.94

2.81–8.71

< 0.01

 

4.65

3.22–8.34

< 0.01

Histology

       

serous carcinomas

1

   

1

  

mucinous carcinoma

0.54

0.25–1.17

0.12

    

endometrioid carcinoma

0.44

0.18–1.09

0.08

    

others

0.37

0.11–1.17

0.09

 

0.58

0.23–1.53

0.28

Grade

       

G1

1

   

1

  

G2

0.59

0.33–1.03

0.06

    

G3

1.76

1.12–2.77

0.01

 

0.89

0.51–1.56

0.69

G4

4.30

2.13–8.67

< 0.01

 

1.44

0.56–3.69

0.45

FIGO stage

       

I

1

   

1

  

II

0.11

0.04–0.30

< 0.01

 

2.21

0.71–8.19

0.34

III

2.32

1.16–4.03

< 0.01

 

8.57

2.65–83.34

< 0.01

IV

5.74

3.60–9.17

< 0.01

 

23.33

5.61–124.79

< 0.01

TGFBIp expression

4.41

2.79–6.97

< 0.01

 

3.65

2.22–5.99

< 0.01

Ki67 expression

1.86

1.17–2.97

< 0.01

 

1.16

0.71–1.89

0.56

EGFR expression

0.74

0.48–1.13

0.16

    

PDL1 expression

1.39

0.89–2.17

0.15