Table 1 Review of the literature on mesonephric-like adenocarcinoma (MLA)

Chapel et al/ 2018 [4]

80

Low-grade serous carcinoma and serous borderline tumor

NA

total abdominal hysterectomy with bilateral salpingooophorectomy, omentectomy, and tumor debulking

Y,neoadjuvant chemotherapy with carboplatin and paclitaxel

N

Three M

diffusely positive for CK7, EMA, and PAX8 ,focally positive for p16, p53‘wildtype’ ,positive for GATA-3, TTF-1, inhibin,p63,CD10,negative for CK20,thyroglobulin,chromogranin, synaptophysin, calretinin, CDX2, parathyroid hormone,PR, WT1, ER

gains in chromosome 1q and 18p and losses in chromosomes 1p, 18q, and 22,mutations in the tumor suppressor genes BCOR or AMER1

predominantly small open and closed tubules, with foci of solid growth and single-cell invasion,Tumor cells were relatively monotonous with mild to moderate cytologic atypia and small nucleoli. Mitotic activity was low (1 to 2 mitotic figures per 10 hpf).

abdominal pain,pelvic mass

11.8*12.5*8.9 cm

1

McCluggage WG et/2020 [5]

61

Serous borderline tumors of both ovaries, low-grade serous carcinomas, and endometriosis

IIIA1

Hysterectomy, bilateral salpingo-oophorectomy, Douglas pouch peritonectomy, omentectomy, and bilateral pelvic lymphadenectomy, peritoneal washout, and cytoreductive surgery

Six cycles of adjuvant chemotherapy (carboplatin and paclitaxel)

NA

NA

PAX8 and CD10 were diffusely positive, GATA3 and TTF1 were focally positive, p53 was “wild type” immunoreactive, and WT1, ER, PR and thyroglobulin were negative

KRAS mutation

Intracavitary eosinophilic secretions, nuclear monomorphism, angulation, moderately atypical, with mitotic and focal necrotic areas

Pelvic pain, increased vaginal discharge, pelvic mass

The maximum size is 6 cm

1

McFarland M/2016 [2]

42 ~ 72,Average age 60

There were 3 cases of endometriosis in the same ovary

IA(3Case),IB(1Case),IIIC(1Case)

NA

NA

Still alive at the time of 12 months

18 months

ER and PR were completely negative, CK 7 and PAX 8 were positive

NA

Tubular, glandular, papillary, falliform and solid structures. The tubules had luminal acidophilic material. The epithelial cells showed moderate nuclear atypia. The nuclei were atypical, clear or cystic and angulated.

NA

The size ranges from 4 to 32 cm

5

Pors, J et/2018 [10]

67

N

IC

NA

NA

NA

NA

ER and reticulin were completely negative, GATA3, TTF1, PAX8 and CD10 were positive

NA

NA

NA

NA

1

Dundr P,et,2020 [7]

61

Serous borderline tumor

IV

Hysterectomy with bilateral salpingo-oophorectomy, resection of hepatic metastases, greater omentum, and appendix

Five cycles of neoadjuvant chemotherapy were followed by adjuvant chemotherapy for 12 months

N

11 months

PAX8,TTF1和 GATA3的阳性

KRAS and PIK3CA somatic mutations.MYCN mutation, loss of exon 9-10 in CHEK2 gene

Tubular, cystic and solid structures. Dense eosinophilic material.The tumor cells were medium in size, dominated by vesicular nuclei and small nucleoli, with 4 /10 HPF

NA

NA

1

Nilforoushan N/2023 [8]

58 and 70 years old

Case 1: Left ovarian serous borderline tumor, right ovarian serous borderline tumor and low grade serous carcinoma. Case 2: Serous borderline tumor of the left ovary

IVB

Total hysterectomy and bilateral salpingo-oophorectomy and omentectomy

NA

NA

NA

GATA3 was diffusely positive, WT-1, ER and PR were negative, p16 was focally and patchy positive, p53 was wild type, Napsin A, TTF-1, CD 10 and PD-L1 were negative

KRAS G12V mutation

NA

NA

NA

2

McCluggage WG et/2018 [17]

50-77 years old, average age 66.5 years old

One case of borderline endometrioid adenoma, one case of endometriosis, mixed serous and mucinous cystadenoma, and one case of serous cystadenoma

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

4

seay/2020 [18]

67

Endometriosis

IA

Exploratory laparotomy, total abdominal hysterectomy, pelvic lymphadenectomy, inferior omental resection, and adhesiolysis were performed

Chemotherapy combined with carboplatin and paclitaxel was given 18 months after surgery for tumor metastasis

Y

NA

CK7 and PAX-8 were strongly positive.HNF 1B, TTF 1, CD 10 and p16 were focally positive, while ER, PR, WT-1 and calretinin were negative.

ATM, PALB 2 gene variation

Tubular, glandular, papillary, chordlike and solid.Cytoplasmic sparseness, nuclear overlap, moderately atypical nuclei with vesicle changes, unmarked nucleolus, and increased mitotic activity

Abdominal pain, polyuria

11 cm

1

樊静华/2022 [20]

60

N

Ib

Total hysterectomy, bilateral adnexa and omentum resection and pelvic adhesiolysis

NA

N

12 months

TTF1, CD10, KatA-3, PAX8, CK7, p16, CK20, CA125, Vimintin, Napsin A were all or partially positive, p53 was expressed in wild type, Ki-67 index was about 30%,ER, PR, WT-1, Calritinin, Ber-EP4 were negative

NA

Papillary, glandular, tubular and sieve shaped arrangement, eosinophilic secretions can be seen in some lumen, the nucleus is round or oval, the nucleolus is not obvious, no mitotic image

Nausea, vomiting, and abdominal distention

7.9 cm×7.3 cm×4.7 cm

1

张方圆/2022 [19]

61

N

IVB

Transabdominal cytoreductive surgery (including bilateral appendectomy, partial colectomy, partial rectal resection, colorectal anastomosis, and omentectomy) was performed

5 courses of paclitaxel + carboplatin chemotherapy

N

13 months

Negative for ER, PR, WT1 and Desmin, positive for PMS2, SALL-4, MLH1, MSH6, MSH2, H-Caldesmon, SMA, AFP and NapsinA, positive for CD10, EMA, CK7, HNF1-β(focally +), Vimentin and CK, GATA3, P16, TTF-1(partial +), α-inhibin(scattered +), P53(weak positive), Ki67(positive 60%)

NA

There were multiple tubular structures with eosinophilic secretions in the lumina

Abdominal distention

12.9 cm×12.2 cm

1

张世凯/2022 [21]

67

Borderline seromucinous neoplasm, endometriosis

IC

Hysterectomy, bilateral adnexa, omentum, appendectomy and pelvic lymph node dissection

Paclitaxel 270 mg and carboplatin 600 mg were given once

NA

4 months

PR was weakly positive, CK20 was scattered positive, Ki-67 proliferation index was 40%,PAX-8 (staining results were unclear), P16, P53 and CK7 were partially positive, CK(AE1/AE3), TTF-1 and GATA3 were positive.ER, CDX2, WT1, calretinin, alpha inhibin, vimentin, HNF1β, NapsinA and P504s were all negative

NA

Papillary, ductal, solid, less cytoplasm, eosinophilic colloid - like secretion in the lumen.Covering epithelium in clusters of hyperplasia.

Pelvic mass and frequent urination

12.2 cm×9.2 cm×9.9 cm

1

present case/2023

45

endometriosis

IIB

Laparoscopic unilateral salpingo-oophorectomy, laparoscopic pelvic lymph node dissection, para-abdominal aortic lymph node dissection, salpingo-oophorectomy, partial resection of small bowel, resection of peritoneal lesions

Paclitaxel (Lioxine) 210 mg+ carboplatin 550 mg chemotherapy for 6 courses

N

4 months

GATA-3, PR, Vim, TTF-, Pax-8, Pax-2, PTEN, B-catenin, MSH2, MSH6, MLH1, PMS2 and wild-type p53 were all positive.NaspinA, D2-40, WT-1, TG were negative,MC and ER were partially positive, Calretinin and CD10 foci were positive, P16(mottled +), Ki-67(+, 30%), HER2(1+).

NA

Multiple tubular structures, eosinophilic secretions found in the cavity

Abdominal pain and pelvic mass

5.0 cm × 3.8 cm × 4.7 cm