Fig. 1
From: Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1
Identification of LNM-Related Genes in Ovarian Cancer. A The volcano map of 509 upregulated LyI-related DEGs (indicated as red dots) and 196 downregulated LyI-related DEGs (indicated as blue dots) (LyI + vs. LyI-; |Fold Change |> 1.5, P-value < 0.05) of TCGA ovarian cancer. B The overlap of DEGs between ovarian cancer tissues and normal ovarian tissues of GSE18520, GSE54388, and GSE27651 from the GEO database. C The overlap of 509 LyI-related up-regulated DEGs of the TCGA database and 661 cancer-related up-regulated DEGs of the GEO database resulted in 12 genes. D The relative mRNA levels of the overlapping 12 genes in ovarian cancer tissues (n = 427, the TCGA database) and normal ovarian tissues (n = 88, the GTEx database); ***P < 0.001. E–F. ROC curve analysis of MEOX1, SPP1, and PCDHB2 in predicting the sample status (normal or tumor) (E) and lymph node metastatic status (LNM + or LNM-) (F) of TCGA ovarian cancer; the value of AUC indicates the diagnostic effect. G. The relative mRNA expression of MEOX1, SPP1, and PCDHB2 in LyI + and LyI- TCGA ovarian cancer; * P < 0.05