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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1

Fig. 4

MEOX1 was Associated with LNM of Ovarian Cancer. A The heat map of DEGs between TCGA ovarian cancer with higher expression of MEOX1 (MEOX1-high) and ovarian cancer with lower expression of MEOX1 (MEOX1-low). B The GSEA analysis of DEGs between MEOX1-high and MEOX1-low TCGA ovarian cancer. C Correlation analysis through the Assistant for Clinical Bioinformatics (ACLBI) website between MEOX1 expression and the pathways of "ECM degradation", "collagen formation", and "ECM-related genes" in ovarian cancer. D The expression correlation between MEOX1 and prolymphangiogenic factors in TCGA ovarian cancer; NS, not statistically significant, *P < 0.05, **P < 0.01, ***P < 0.001 (Spearman analysis). E The correlation analysis via the GEPIA2.0 database between the expression of MEOX1 and the expression of ten prolymphangiogenic factors including VEGF-C, VEGF-D, TGFB2, TGFB3, IGF-1, IGF-2, FGF-1, PDGF-A, PDGF-B, PDGF-C, and PDGF-D in ovarian cancer tissues. F The mRNA level of MEOX1 in TCGA ovarian cancer with a lower PDPN expression (PDPN-low) or a higher PDPN expression (PDPN-high). G. The mRNA expression of MEOX1 in TCGA ovarian cancer with a lower LYVE-1 expression (LYVE-1-low) or a higher LYVE-1 expression (LYVE-1-high)

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