Fig. 5
From: Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1
MEOX1 was Abnormally Upregulated in Ovarian Cancer and was Associated with Lymph Node Metastasis. A-C RT-qPCR assays and western blot assays were used to detect the mRNA levels (A) and the protein levels (B-C) of MEOX1 in normal ovarian epithelial cell line IOSE-80 and ovarian cancer cell lines (OVCAR5, HO8910, A2780, and SKOV3); *P < 0.05, **P < 0.01, ***P < 0.001 vs. IOSE-80. D. RT-qPCR assays were used to detect the relative mRNA expression of MEOX1 in clinical HGSOC samples (n = 14) and normal ovarian tissue samples (n = 8). E–F The representative images of MEOX1 IHC staining (E) and statistical results of MEOX1 IHC scores (F) in normal ovarian tissue samples (n = 8), LNM- HGSOC tissue samples (n = 12), and LNM + HGSOC tissue samples (n = 20). G Statistical results of MEOX1 IHC Score in tumor cells and tumor stroma of 32 HGSOC tissues. E The mRNA levels of MEOX1 in A2780, SKOV3, and primary CAFs of ovarian cancer