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Fig. 8 | Journal of Ovarian Research

Fig. 8

From: Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents

Fig. 8

Enrichment analysis of predicted pathways regulated by differently and exclusive expressed miRNAs present in small extracellular vesicles miRNAs from follicular fluid. (A) Predicted pathways modulated by two (bta-miR-34c; bta-miR-26c) exclusive sEVs miRNAs and three sEVs miRNAs (bta-miR-17-5p, bta-miR-34b, and bta-miR-374a) upregulated in ipsilateral (high P4) to the corpus luteum follicles. (B) Predicted pathways modulated by two (bta-miR-628; bta-miR-369-5p) exclusive sEVs miRNAs and seven sEVs miRNAs (bta-miR-197, bta-miR-205, bta-miR-3064, bta-miR-330, bta-miR-544b, bta-miR-409b, and bta-miR-1296) upregulated in contralateral (low P4) to the corpus luteum follicles. Graphs A (all pathways) and B (first 10 pathways) represent the pathways adjusted by the BH value (p<0.05) with a significant level. The left Y-axis values represent the percent of genes modulated by the exclusive and upregulated miRNAs, calculated by the ratio of all genes present in each pathway. The right Y-axis represents the BH value of the pathways predicted with miRWalk 3.0 software

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Journal of Ovarian Research

ISSN: 1757-2215

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