Table 1 Univariate and multivariate Cox proportional hazards regression analysis of the OS of ovarian cancer patients

Age

 01-14 years

Reference

 15-29 years

2.69 (1.84-3.92)

<0.001

2.34 (1.61-3.42)

<0.001

 30-44 years

6.72 (4.66-9.69)

<0.001

4.20 (2.91-60.07)

<0.001

 45-49 years

10.81 (7.51-15.56)

<0.001

5.52 (3.82-7.96)

<0.001

 60-74 years

16.34 (11.35-23.51)

<0.001

7.02 (4.87-10.13)

<0.001

 75+ years

33.81 (23.49-48.68)

<0.001

11.49 (7.96-16.58)

<0.001

Race

 White

Reference

 Black

1.24 (1.21-1.28)

<0.001

1.25 (1.21-1.29)

<0.001

 Asian or Pacific Islander

0.70 (0.68-0.73)

<0.001

0.91 (0.88-0.94)

<0.001

 American Indian/Alaska Native

1.06 (0.96-1.18)

0.236

1.17 (1.05-1.30)

0.003

Chemotherapy

 No

Reference

 Yes

1.10 (1.08-1.12)

<0.001

0.67 (0.65-0.68)

<0.001

Summary stage

 Distant

Reference

 Localized

0.13 (0.13-0.14)

<0.001

0.16 (0.16-0.17)

<0.001

 Regional

0.29 (0.28-0.30)

<0.001

0.36 (0.35-0.37)

<0.001

 Unknown/unstaged

0.74 (0.71-0.78)

<0.001

0.47 (0.45-0.50)

<0.001

Surgery

 Cytoreductive surgery

Reference

 No

3.27 (3.19-3.35)

<0.001

2.71 (2.64-2.78)

<0.001

 Other

1.03 (0.95-1.11)

0.525

1.28 (1.18-1.39)

<0.001

 Palliative surgery

0.44 (0.43-0.45)

<0.001

0.81 (0.79-0.83)

<0.001

ICD-O-3

Reference

 Adenocarcinoma

Reference

 Epithelial carcinoma

1.74 (1.68-1.81)

<0.001

1.19 (1.14-1.24)

<0.001

 Other types

0.41 (0.39-0.43)

<0.001

0.73 (0.69-0.76)

<0.001

 Sarcoma

1.82 (1.75-1.89)

<0.001

1.64 (1.57-1.70)

<0.001

Year of diagnose

 2000-2005

Reference

 2006-2011

0.93 (0.91-0.95)

<0.001

0.95 (0.93-0.97)

<0.001

 2012-2017

0.87 (0.85-0.89)

<0.001

0.87 (0.85-0.89)

<0.001