Table 1 Summary of promoters and targeted genes for ovarian epithelial tumorigenesis.
From: Ovarian cancer mouse models: a summary of current models and their limitations
Authors | Promoter | Targeted gene | Tumorigenesis | Limitation |
|---|---|---|---|---|
Orsulic et al. (2002) | keratin-5, RCAS | TVA, p53-/-, oncogenes | Yes | External manipulation |
Connolly et al. (2003) | MISIIR | SV40 TAg | Yes | Inhibited female reproduction |
Flesken-Nikkita et al. (2003) | AdCre | p53-/- & Rb-/- | Yes | Transient expression |
Dinulescu et al. (2005) | AdCre | K-ras & PTEN-/- | Yes | Transient expression |
Wu et al. (2007) | AdCre | PTEN-/- & APC-/- | Yes | Transient expression |
Chondankar et al. (2005) | FSHR | Cre, BRCA1-/- | No | Â |
Clark-Knowles et al. (2007) | AdCre | BRCA1Δ5-13 | No | Transient expression |
El-Naggar et al. (2007) | MISIIR | PTTG | No | Â |
Liang et al. (2009) | MISIIR | PIK3CA | No | Â |