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  1. This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning.

    Authors: Wang-Yu Cai, Xi Luo, Wei Wu, Jianyuan Song, Ning-Ning Xie, Cuicui Duan, Xiao-Ke Wu and Jian Xu
    Citation: Journal of Ovarian Research 2022 15:109
  2. This study investigated whether high physical activity affects ovarian reserve in normo-ovulatory, reproductive-age women.

    Authors: Netanella Miller, Yael Pasternak, Einat Haikin Herzberger, Hadar Gluska, Chen Dorenstein, Roni Rahav, Rina Hemi, Nahid Zada and Amir Wiser
    Citation: Journal of Ovarian Research 2022 15:107
  3. Ovarian cancer is a common gynecological cancer with poor prognosis and poses a serious threat to woman life and health. In this study, we aimed to establish a prognostic signature for the risk assessment of o...

    Authors: Qi-jia Li, Juan Wang, Jing Jiang and Bing Lin
    Citation: Journal of Ovarian Research 2022 15:106
  4. Ovarian neoplasia in children and adolescents is a rare tumor. The diagnosis and management of such tumors is often difficult and delayed due to non-specific symptoms and low suspicion. Surgical management tha...

    Authors: Lateefa AlDakhil, Asma Aljuhaimi, Mashael AlKhattabi, Saleh Alobaid, Rafif E. Mattar and Abdulaziz Alobaid
    Citation: Journal of Ovarian Research 2022 15:105
  5. Ovarian malignant mesoderm mixed tumor (OMMMT) is a rare clinical entity. To provide reference for the treatment and prognosis of OMMMT, we analyzed the clinical features, pathology and molecular biology chara...

    Authors: Xin Wang, Shiyuan Wang, Shujuan Yao, Wei Shi and Ke Ma
    Citation: Journal of Ovarian Research 2022 15:104
  6. Ubiquitin-binding enzyme E2T (UBE2T), a member of the E2 family of the ubiquitin–proteasome pathway, is associated with tumorigenesis of varioustumours; however, its role and mechanism in ovarian cancer remain...

    Authors: Ping Cui, Hao Li, Can Wang, Yuan Liu, Mengjun Zhang, Yue Yin, Zhenxing Sun, Yiru Wang and Xiuwei Chen
    Citation: Journal of Ovarian Research 2022 15:103
  7. Artificial oocyte activation (AOA) is used to improve fertilization rate following fertilization failure after intracytoplasmic sperm injection (ICSI). Several studies have also shown that AOA may be involved ...

    Authors: Tzung-En Tsai, Pei-Hsuan Lin, Pei-Fen Lian, Chia-Jung Li, Salvatore Giovanni Vitale, Mislav Mikuš, Wan-Ping Su, Hsiao-Wen Tsai, Kuan-Hao Tsui and Li-Te Lin
    Citation: Journal of Ovarian Research 2022 15:102
  8. Ovarian aging refers to the process by which ovarian function declines until eventual failure. The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is considered to be a key factor. ...

    Authors: Fei Yan, Qi Zhao, Ying Li, Zhibo Zheng, Xinliang Kong, Chang Shu, Yanfeng Liu and Yun Shi
    Citation: Journal of Ovarian Research 2022 15:100
  9. Non-SMC condensin I complex subunit G (NCAPG), a member of the subunit of condensin complex, is significantly overexpressed in various cancers and involved in the pathogenesis of cancers. However, the roles of...

    Authors: Haiting Yu, Dan Zou, Na Ni, Suxian Zhang, Qin Zhang and Lihua Yang
    Citation: Journal of Ovarian Research 2022 15:98
  10. Pegylated liposomal doxorubicin (PLD) is a nano-doxorubicin anticancer agent. It was used as early as 2014 to treat ovarian and breast cancer, multiple myeloma and Kaposi's sarcoma. The 2018 National Comprehen...

    Authors: Xin-Ru Li, Xing-Han Cheng, Guo-Nan Zhang, Xiao-Xin Wang and Jian-Ming Huang
    Citation: Journal of Ovarian Research 2022 15:96
  11. Circular RNAs (circRNAs) are reported to be key regulators in the progression of human cancers. This work focuses on the function and molecular mechanism of circRNA-BNC2 (circ-BNC2) (also known as hsa_circ_000...

    Authors: Ting Liu, Li Yuan and Xiaofeng Zou
    Citation: Journal of Ovarian Research 2022 15:95
  12. Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated...

    Authors: Jingchun Liu, Shasha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng and Li Hong
    Citation: Journal of Ovarian Research 2022 15:93
  13. Recently, increasing evidence has indicated that elevation of Hexokinase 2 (HK2) plays an important role in several cancers on regulating cell motility and growth. However, its role on regulating cell EMT in h...

    Authors: Xueye Tian, Dan Liu, Xiaohang Zuo, Xiaoli Sun, Mengmin Wu, Xu Li and Yue Teng
    Citation: Journal of Ovarian Research 2022 15:92
  14. During embryonic development, the normality of cleavage and the ploidy state are closely related to the final clinical outcome. At present, many research teams are focusing on the combined application of timel...

    Authors: Lei Jin, Xiyuan Dong, Wei Tan and Bo Huang
    Citation: Journal of Ovarian Research 2022 15:91
  15. Many factors can affect the recurrence of endometriosis after surgery, however, whether endometriotic cyst fluid contributes to endometriosis recurrence after surgical excision of ovarian endometriomas remains...

    Authors: Xinxin Xu, Yichen Chen, Qin Yu, Jianzhang Wang, Ping Xu, Libo Zhu, Qiong Xu, Jing Zhang, Shuling Cui, Kewen Yu, Tiantian Li, Xinyue Guo and Xinmei Zhang
    Citation: Journal of Ovarian Research 2022 15:89
  16. Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells. Experiments were performed ...

    Authors: Szymon Rutecki, Paulina Szulc, Martyna Pakuła, Paweł Uruski, Artur Radziemski, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Justyna Mikuła-Pietrasik and Krzysztof Książek
    Citation: Journal of Ovarian Research 2022 15:87
  17. Granulosa cells (GCs) are multilayered somatic cells within the follicle that provide physical support and microenvironment for the developing oocyte. In recent years, the role of Neuregulin-1 (NRG1), a member...

    Authors: Saswati Banerjee, Sameer Mishra, Wei Xu, Winston E. Thompson and Indrajit Chowdhury
    Citation: Journal of Ovarian Research 2022 15:86
  18. The postnatal mammalian ovary undergoes a series of changes to ensure the maturation of sufficient follicles to support ovulation and fecundation over the reproductive life. It is well known that intracellular...

    Authors: Daniel Bahena-Alvarez, Diana Millan-Aldaco, Ruth Rincón-Heredia, Nancy Escamilla-Avila and Arturo Hernandez-Cruz
    Citation: Journal of Ovarian Research 2022 15:85
  19. Ovarian clear cell carcinoma (OCCC) is the most common endometriosis-associated ovarian cancer. Ovarian endometriosis may present with atypical or malignant sonographic features and interfere with clinical jud...

    Authors: Kuan-Ju Huang, Ying-Xuan Li, Chin-Jui Wu, Wen-Chun Chang, Lin-Hung Wei and Bor-Ching Sheu
    Citation: Journal of Ovarian Research 2022 15:84
  20. Ovarian cancer (OC), a frequent malignant tumor that affects women, is one of the leading causes of cancer-related death in this group of individuals. For the treatment of ovarian cancer, systemic chemotherapy...

    Authors: Ahmad Saburi, Mohammad Saeed Kahrizi, Navid Naghsh, Hasti Etemadi, Ahmet İlhan, Ali Adili, Shadi Ghoreishizadeh, Rozita Tamjidifar, Morteza Akbari and Gülinnaz Ercan
    Citation: Journal of Ovarian Research 2022 15:81
  21. The delay of ovarian aging and the fertility preservation of cancer patients are the eternal themes in the field of reproductive medicine. Acting as the pacemaker of female physiological aging, ovary is also c...

    Authors: Wenli Hong, Baofeng Wang, Yasha Zhu, Jun’e Wu, Li Qiu, Shuyi Ling, Ziqiong Zhou, Yuqing Dai, Zhisheng Zhong and Yuehui Zheng
    Citation: Journal of Ovarian Research 2022 15:79
  22. Numerous studies have indicated that the level of the Anti-Müllerian hormone (AMH), one of the main markers for the ovarian reserve, does not fluctuate throughout a menstrual cycle, while some studies have rej...

    Authors: Rasa Khodavirdilou, Marjaneh Pournaghi, Yeganeh Rastgar Rezaei, Khadijeh Hajizadeh, Lida Khodavirdilou, Farzin Javid, Kobra Hamdi, Mahnaz Shahnazi, Mohammad Nouri, Amir Fattahi, Matthias W. Beckmann and Ralf Dittrich
    Citation: Journal of Ovarian Research 2022 15:78
  23. Ying Yang1 (YY1) has already been discussed in oral squamous cell carcinoma (OSCC), but the knowledge about its mediation on long non-coding RNA KCNQ1 overlapping transcript 1/microRNA-506-3p/synaptophysin lik...

    Authors: Yi Ding, Heng Duan, Jian Lin and Xuanxuan Zhang
    Citation: Journal of Ovarian Research 2022 15:77
  24. Studies have revealed the implications of cancer-associated fibroblasts (CAFs) in tumor progression, metastasis, and treatment resistance. Here, in silico analyses were performed to reveal the key genes and pa...

    Authors: Li Han, Xiaojuan Guo, Ruijuan Du, Kelei Guo, Pei Qi and Hua Bian
    Citation: Journal of Ovarian Research 2022 15:75
  25. Infertility remains a significant public health concern. An issue with controlled ovarian stimulation (COS) is the selection of an exogenous gonadotropin (Gn) regimen, which is mainly based on urinary follicle...

    Authors: Chunxia Yang, Naijun Dong, Feng Li, Yurong Ji, Yu Pan and Hong She
    Citation: Journal of Ovarian Research 2022 15:74
  26. High grade epithelial ovarian cancer (EOC) represents a diagnostic and therapeutic challenge due to its aggressive features and short recurrence free survival (RFS) after primary treatment. Novel targets to in...

    Authors: Monika Sobočan, Daniela Brunialti, Sussanne Sprung, Christoph Schatz, Jure Knez, Rajko Kavalar, Iztok Takač and Johannes Haybaeck
    Citation: Journal of Ovarian Research 2022 15:73
  27. Among many gynecological malignancies ovarian cancer is the most prominent and leading cause of female mortality worldwide. Despite extensive research, the underlying cause of disease progression and pathology...

    Authors: Anam Beg, Rafat Parveen, Hassan Fouad, M. E. Yahia and Azza S. Hassanein
    Citation: Journal of Ovarian Research 2022 15:72
  28. Highly differentiated follicular carcinoma (HDFCO) is a rare form of struma-derived thyroid-type carcinoma in ovary, defined as ovarian struma spreading beyond ovary but consisting of benign thyroid tissues. N...

    Authors: Yi-Ting Bao, Chao Wang, Wu Huang, Liang-Qing Yao and Lei Yuan
    Citation: Journal of Ovarian Research 2022 15:71
  29. Mitochondrial dynamics (e.g. fission/fusion) play an important role in controlling chemoresistance in representative gynecologic malignancies, ovarian and cervical cancer. Processing the long form of Optic atr...

    Authors: Bao Kong, Chae Young Han, Se Ik Kim, David A. Patten, Youngjin Han, Euridice Carmona, Dar-Bin Shieh, Annie C. Cheung, Anne-Marie Mes-Masson, Mary-Ellen Harper, Yong Sang Song and Benjamin K. Tsang
    Citation: Journal of Ovarian Research 2022 15:70
  30. Dysregulation of Ectonucleoside Triphospahate Diphosphohydrolase 5 (ENTPD5) in tumors might be associated with tumor progression, while the role of ENTPD5 in the growth and metastasis of serous ovarian cancer ...

    Authors: Xueping Chen, Zhiqiang Zha, Yu Wang, Yun Chen, Menglan Pang, Liping Huang and Yao Chen
    Citation: Journal of Ovarian Research 2022 15:69
  31. Mature cystic teratomas of the ovary (MCTO) are a type of germ cell tumor that may contain well-differentiated tissues developed from three germ cell layers and constitute about 20% of ovarian germ cell tumors...

    Authors: Stefano Palomba, Tiziana Russo, Giuseppe Albonico and Marcello Tripodi
    Citation: Journal of Ovarian Research 2022 15:68
  32. Ovarian cancer is composed of a complex system of cells best described by features such as clonal evolution, spatial and temporal genetic heterogeneity, and development of drug resistance, thus making it the m...

    Authors: Patriciu Achimas-Cadariu, Paul Kubelac, Alexandru Irimie, Ioana Berindan-Neagoe and Frank Rühli
    Citation: Journal of Ovarian Research 2022 15:67
  33. Rising evidences bespeak that circular RNAs are indispensable in regulating cellular biological behaviors and engaging in diseases' occurrence. CircRHOBTB3 has been reported to participate intimately in the pr...

    Authors: Yihan Fu and Hong Sun
    Citation: Journal of Ovarian Research 2022 15:66
  34. To evaluate the diagnostic utility of conventional magnetic resonance imaging (MRI)-based characteristics and a texture analysis (TA) for discriminating between ovarian thecoma-fibroma groups (OTFGs) and ovari...

    Authors: Keita Nagawa, Tomoki Kishigami, Fumitaka Yokoyama, Sho Murakami, Toshiharu Yasugi, Yasunobu Takaki, Kaiji Inoue, Saki Tsuchihashi, Satoshi Seki, Yoshitaka Okada, Yasutaka Baba, Kosei Hasegawa, Masanori Yasuda and Eito Kozawa
    Citation: Journal of Ovarian Research 2022 15:65
  35. Circulating leukocytes are an important part of the immune system. The aim of this work is to explore the role of preoperative circulating leukocytes in serous ovarian carcinoma and investigate whether they ca...

    Authors: Ying Feng, Zhixiang Wang, Ran Cui, Meizhu Xiao, Huiqiao Gao, Huimin Bai, Bert Delvoux, Zhen Zhang, Andre Dekker, Andrea Romano, Shuzhen Wang, Alberto Traverso, Chongdong Liu and Zhenyu Zhang
    Citation: Journal of Ovarian Research 2022 15:64
  36. The prognostic value of the expression of estrogen receptor (ER) subtypes ER⍺ and ERβ in ovarian cancer has previously been evaluated by meta-analyses. However, the results are contradictory and controversial.

    Authors: Chun Wai Ng and Kwong-Kwok Wong
    Citation: Journal of Ovarian Research 2022 15:63
  37. Blastomere loss is a common phenomenon that occurs following cryopreservation. To date, studies have drawn conflicting conclusions regarding the impact of blastomere loss on pregnancy outcomes. Besides, limite...

    Authors: Shutian Jiang, Wei Jin, Xinxi Zhao, Qianwen Xi, Li Chen, Yining Gao, Wenzhi Li and Yanping Kuang
    Citation: Journal of Ovarian Research 2022 15:62
  38. Emerging evidence identifies enhancer RNAs (eRNAs) as a class of regulatory ncRNAs that can contribute to the transcription of target genes. In this study, we used an integrated data analysis method to identif...

    Authors: Jiaya Mo, Lianghao Zhang, Huiqing Li, Haoran Duan, Dong Wang, Xiaolei Zhao and Ya Xie
    Citation: Journal of Ovarian Research 2022 15:61
  39. Greater ovulatory years is associated with increased ovarian cancer risk. Although ovulation leads to an acute pro-inflammatory local environment, how long-term exposure to ovulation impacts ovarian carcinogen...

    Authors: Naoko Sasamoto, Paul A. Stewart, Tianyi Wang, Sean J. Yoder, Srikumar Chellappan, Jonathan L. Hecht, Brooke L. Fridley, Kathryn L. Terry and Shelley S. Tworoger
    Citation: Journal of Ovarian Research 2022 15:59

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