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  1. Research

    Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer

    Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat...

    Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji and Shu Zhang

    Journal of Ovarian Research 2017 10:69

    Published on: 11 October 2017

  2. Research

    Macrophage colony-stimulating factor (M-CSF) is an intermediate in the process of luteinizing hormone-induced decrease in natriuretic peptide receptor 2 (NPR2) and resumption of oocyte meiosis

    Luteinizing hormone (LH) regulation of the ligand, natriuretic peptide precursor type C, and its receptor, natriuretic peptide receptor 2 (NPR2), is critical for oocyte maturation; however, the mechanism is no...

    Wenchao Sun, Chang Liu, Ying Feng, Guangchao Zhuo, Wenjing Zhou, Xiaoyang Fei and Zhifen Zhang

    Journal of Ovarian Research 2017 10:68

    Published on: 4 October 2017

  3. Research

    Increased RHAMM expression relates to ovarian cancer progression

    Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM’s role in ovarian...

    Stephanie T. Buttermore, Mitchel S. Hoffman, Ambuj Kumar, Anne Champeaux, Santo V. Nicosia and Patricia A. Kruk

    Journal of Ovarian Research 2017 10:66

    Published on: 27 September 2017

  4. Review

    Racial health disparities in ovarian cancer: not just black and white

    Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC...

    Sanjeev K. Srivastava, Aamir Ahmad, Orlandric Miree, Girijesh Kumar Patel, Seema Singh, Rodney P. Rocconi and Ajay P. Singh

    Journal of Ovarian Research 2017 10:58

    Published on: 21 September 2017

  5. Research

    Activated ovarian endothelial cells promote early follicular development and survival

    New data suggests that endothelial cells (ECs) elaborate essential “angiocrine factors”. The aim of this study is to investigate the role of activated ovarian endothelial cells in early in-vitro follicular dev...

    Alon Kedem, Anate Aelion-Brauer, Peipei Guo, Duancheng Wen, Bi-Sen Ding, Raphael Lis, Du Cheng, Vladislav M. Sandler, Shahin Rafii and Zev Rosenwaks

    Journal of Ovarian Research 2017 10:64

    Published on: 19 September 2017

  6. Research

    Biological effects of combined resveratrol and vitamin D3 on ovarian tissue

    Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low ...

    Francesca Uberti, Vera Morsanuto, Silvio Aprile, Sabrina Ghirlanda, Ian Stoppa, Andrea Cochis, Giorgio Grosa, Lia Rimondini and Claudio Molinari

    Journal of Ovarian Research 2017 10:61

    Published on: 15 September 2017

  7. Research

    Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

    PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagn...

    Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf and Tayyaba Afsar

    Journal of Ovarian Research 2017 10:62

    Published on: 15 September 2017

  8. Research

    The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells

    Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely relate...

    Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang and Chuanna Liu

    Journal of Ovarian Research 2017 10:60

    Published on: 12 September 2017

  9. Research

    Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo

    Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primor...

    Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin and Qingxue Zhang

    Journal of Ovarian Research 2017 10:56

    Published on: 16 August 2017

  10. Research

    A prospective study to evaluate the risk malignancy index and its diagnostic implication in patients with suspected ovarian mass

    There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite metho...

    Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande and Jatindra Prasad Hota

    Journal of Ovarian Research 2017 10:55

    Published on: 14 August 2017

  11. Research

    Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study

    Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the en...

    Ricardo Santos Simões, José Maria Soares-Jr, Manuel J. Simões, Helena B. Nader, Maria Cândida P. Baracat, Gustavo Arantes R. Maciel, Paulo C. Serafini, Ricardo Azziz and Edmund C. Baracat

    Journal of Ovarian Research 2017 10:54

    Published on: 8 August 2017

  12. Research

    Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma

    Ovarian carcinoma is highly dependent on the ubiquitin proteasome system (UPS), but its clinical response to treatment with the proteasome inhibitor bortezomib has been disappointing. This has driven explorati...

    Rosie T. Jiang, Anna Yemelyanova, Deyin Xing, Ravi K. Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D. Seidman, Tian-Li Wang and Richard B. S. Roden

    Journal of Ovarian Research 2017 10:53

    Published on: 7 August 2017

  13. Research

    A retrospective study of reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors and sex cord-stromal tumors

    To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST).

    Ning Zhang, Ruifang Chen, Keqin Hua and Ying Zhang

    Journal of Ovarian Research 2017 10:52

    Published on: 27 July 2017

  14. Research

    Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression

    Discoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers the progression of various cancers. Aberrant expression of DDR1 was detected in several human cancers...

    Yuao Deng, Fang Zhao, Liu Hui, Xiuyun Li, Danyu Zhang, Wang Lin, Zhiqiang Chen and Yingxia Ning

    Journal of Ovarian Research 2017 10:50

    Published on: 25 July 2017

  15. Research

    R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency

    R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle de...

    Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young and Nadine Binart

    Journal of Ovarian Research 2017 10:51

    Published on: 25 July 2017

  16. Research

    Enterolactone has stronger effects than enterodiol on ovarian cancer

    Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development of drug resistance. As a result, this disease has low...

    Huidi Liu, Jianrui Liu, Siwen Wang, Zheng Zeng, Ting Li, Yongfang Liu, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Sijing Hu, Shan Gao, Yingying Qi, Zhihang Shen, Hongyue Wang…

    Journal of Ovarian Research 2017 10:49

    Published on: 24 July 2017

  17. Research

    Ovarian preservation in adenocarcinoma of the uterine cervix

    An upward trending incidence in cervical adenocarcinoma (ADC) has been reported in many countries. Because non-squamous histology has been associated with increased risk of ovarian metastases (OM), bilateral o...

    Jiansong Zhou, Yuanyuan Chen, Ping Zhang and Hanmei Lou

    Journal of Ovarian Research 2017 10:48

    Published on: 24 July 2017

  18. Research

    Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro

    In human IVF, embryos cultured with a lower O2 tension (5%) can give rise to higher success rates when compared with normoxic conditions (20%). However, the mechanisms behind the beneficial effects of reduced oxy...

    Yun-Yi Ma, Huei-Wen Chen and Chii-Ruey Tzeng

    Journal of Ovarian Research 2017 10:47

    Published on: 20 July 2017

  19. Case report

    A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

    Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology...

    Nan Jia, Yan Chen, Xiang Tao, Enzhi Ou, Xin Lu and Weiwei Feng

    Journal of Ovarian Research 2017 10:46

    Published on: 20 July 2017

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