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Table 4 Relationship between preoperative absolute serum CA125 levels and survival in ovarian cancer

From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

First Author, Year, Study Place Data Collection Study Design Sample Size Groups being Compared RR/HR, (95% CI), P-Value Conclusion Variables Adjusted for
Osman N, 2008, Limerick [53] Jan 2001 to Dec 2005 Retrospective study 75 ≤ 500 u/ml, > 500 u/ml NA, 0.85 The preoperative CA125 level did not correlate significantly with stage, tumor grade or survival Age, histology, FIGO stage, grade
Petri A, 2006, Denmark [54] Dec 1994 to May 1999 Retrospective study 118 < 65 U/mL, ≥ 65 U/mL 3.4 (1.2--9.6), 0.01 Patients with stage I EOC and preoperative serum CA125 levels < 65 U/mL had a significantly longer survival compared to those with serum CA125 ≥ 65 U/mL Age, histology FIGO substage, grade, chemotherapy
Cooper BC, 2002, USA [55] 1990 to 1996 Retrospective study 142 < 160, 160--399, 400--924, 925--2399, 2400 U/mL GI-Reference, GII-2, GIII-1.5, GIV-4, GV-2, 0.03 (for trend) There was a significant association between CA125 levels and disease-specific survival Age, histology FIGO stage, grade, ascites, and optimal cytoreduction
Buller R, 1996, USA [56] 1987 to 1982 Retrospective study 126 ≤ 500 U/ml, > 500 U/ml, ≤ 3000 U/ml, > 3000 U/ml I-HR-NA, 0.48
II-HR-NA, 0.65
Preoperative CA125 levels did not predict survival advantage over a range of cut points (400 to 3000 U/ml) Age, histology, FIGO stage, tumor grade, residual disease, time to initial chemotherapy
Geisler JP, 1996, USA [57] NA Consecutive case series 82 NA NA, 0.047 In epithelial ovarian carcinoma, high preoperative serum levels of CA125 predict decreased length of survival Histology
FIGO substage, grade
Gadducci A, 1995, Italy [40] 1986 to 1992 Multicentric retrospective study 225 ≥ 500 U/ml, < 500 U/ml NA Serum CA125 half-life during early chemotherapy was an independent prognostic factor for survival FIGO stage, tumor grade, size of residual disease & serum CA125 half life
Nagele F, 1995, Austria [58] Jan 1984 to June 1993 Retrospective study 201 < 65 U/mL, ≥ 65 U/mL Uni-7.45 (2.83-19.65), < 0.001
Multi-6.37 (2.39-16.97), < 0.001
Preoperative CA125 was the most powerful prognostic factor for survival Age, FIGO substage, grade,
Makar AP, 1992, Norway [59] 1983 to 1990 Prospective study 200 ≤ 150 U/ml, > 150 U/ml NA, 0.035 Preoperative CA125 did not appear to be of any prognostic value in epithelial ovarian cancer NA
Sevelda P, 1989, Austria [60] NA Prospective study 163 ≥ 35 U/ml, < 35 U/ml NA, 0.13 Preoperative CA125 was not a predictor of survival Histologic grade, FOGO stage, residual tumor
Moebus V, 1988, Germany [61] NA Convenience sample 202 ≥ 65 U/ml, < 65 U/ml NA, 0.005 Significantly longer survival was noted for patients with preoperative values below 65 U/ml than for those with values above 65 U/ml NA
Cruickshank D, 1987, Aberdeen [62] NA Prospective study 52 ≥ 35 U/ml, < 35 U/ml NA No correlation was found between CA125 concentration and survival NA