Table 5 Relationship between postoperative absolute serum CA125 levels and survival in ovarian cancer
From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature
First Author, Year, Study Place | Data Collection | Study Design | Sample Size | Groups being Compared | RR/HR, (95% CI), P-Value | Conclusion | Variables Adjusted for |
|---|---|---|---|---|---|---|---|
Osman N, 2008, Limerick [53] | Jan 2001 to Dec 2005 | Retrospective study | 68 | ≤ 500 U/ml, > 500 U/ml | NA, < 0.01 | The postoperative CA125 correlated to FIGO stage, tumor grade and overall survival. Reduced survival was noted with increasing age at the time of surgery and bulk of the residual disease postoperatively. | Age, histology, FIGO stage, grade |
Munstedt K, 1997, Germany [63] | 1987 to 1994 | Retrospective study | 85 | < 60 U/ml, > 60 U/ml, > 480 U/ml | NA | Serum CA125 levels within 4 weeks of operation were of no significant value as indicators of overall survival | Age, FIGO stage, histology, grades |
Makar AP, 1992, Norway [59] | 1983 to 1990 | Prospective study | 487 | ≤ 35 U/ml, 36-65 U/ml, > 65 U/ml | I-1.00, (Reference), II- 1.56 (0.82-2.80), NS, III- 2.40 (1.42-4.06), 0.0008 | In patients without residual disease after primary surgery, histologic type, postoperative CA125 level with 35 U/mL as the cutoff value, and tumor grade were independent prognostic factors for survival | Size of residual disease, histology, FIGO stage, tumor grade |
Sevelda P, 1989, Austria [60] | NA | Prospective study | 132 | ≥ 35 U/ml, < 35 U/ml | NA, 0.0006 | Postoperative CA125 was the strongest independent prognostic factor for survival | Histologic grade, FOGO stage, residual tumor |
Moebus V, 1988, Germany [61] | NA | Convenience sample | 165 | ≥ 65 U/ml, < 65 U/ml | NA, 0.001 | Significantly longer survival was noted for patients with postoperative values below 65 U/ml than for those patients with postoperative values above 65 U/ml | NA |