Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Table 3 Metabolism/Cell Adhesion/Cytoskeletal/Structural

Gene Symbol	Name	Entrez Gene ID	Group
Acta2	Actin, alpha 2, smooth muscle, aorta	11475	E16
Bpgm	2,3-bisphophoglycerate mutase	12183	E16, P0
Casq1	Calsequestrin 1	12372	RA +4.4
Dlg5	Discs, large homolog 5	71228	NA-3.7, RA-3.6, E13
Erp29	Endoplasmic reticulum protein 29	67397	E16, P0
Hspg2	Heparin sulfate proteoglycan 2	15530	E16, P0
Itih5	Inter-alpha (globulin) inhibitor H5	209378	E16
Klk13*	Kallikrein related-peptidase 13	626834	RA +3.3
Odc1	Ornithine decarboxylase, structural 1	18263	E16
Slc12a2	Solute carrier family 12, member 2	20496	E16, P0
StAR***	Steroidogenic acute regulatory protein	20845	MA+2.7, MR+3.9
Thbs2	Thrombospondin 2	21826	E13, E16
Usp9x	Ubiquitin specific peptidase 9, X chromosome	22284	E13, P0
Vldlr	Very low density lipoprotein receptor	22359	MR +2.1

All genes listed that do not have an asterisk after the gene symbol are common to our study and the in vivo in mouse ovary study only [7]. Genes denoted by a single asterisk* are common to our study and the human KGN cell line only [6]. Those indicated by ** are common to all three studies. The (-) symbol indicates fold decreased expression. The (+) symbol indicates fold increased expression. MA compares mock (M) transfected cells to activated (A) cells (Foxl2-VP16 transfected). MR compares mock (M) transfected to repressed (R) cells (Foxl2-Mad transfected). RA compares repressed to activated cells. E16 and E13 are mouse embryonic stages day 16 and 13, respectively. P0 is mouse birth stage.

ISSN: 1757-2215