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Table 3 Expression and their biological functions of genes in mural granulosa cells of follicles containing oocyte with normal developmental competence compared to those with poor developmental competence, as determined by Gene Ontology Analysis

From: Mural granulosa cell gene expression associated with oocyte developmental competence

Probe position at array Fold changes* Gene Biological functions
Transcription regulation genes
1367847 1.8 Nuclear protein 1 Unknown
1384308 1.6 Meis1 (myeloid ecotropic viral integration site 1 homolog) Regulation of transcription, DNA dependent
1371947 1.6 Necdin Unknown
1371822 1.5 RNA polymerase III (DNA directed) polypeptide D Regulation of progression through cell cycle
1375414 1.5 TAF9 RNA polymerase II [TATA box binding protein (TBP)-associated factor] Negative regulation of transcription from RNA polymerase II promoter
1390116 1.4 Transcribed locus: similar to polymerase I-transcript release factor (PTRF) Unknown
1374780 1.3 Transcribed locus Unknown
1372093 1.3 Max interacting protein 1 Unknown
1373978 1.3 Nuclear cap binding protein subunit 1 (80 kDa) RNA splicing and Mrna cleavage
1385486 1.3 Transcribed locus Unknown
1380827 1.3 Similar to C1orf25 tRNA processing
1370826 1.3 Nucleosome assembly protein 1-like 1 DNA replication, nucleosome assembly and positive regulation of cell proliferation
1376597 1.3 Ninc finger, CCHC domain containing 10 Unknown
1388067a -1.3 Glucocorticoid modulatory element binding protein 2 Regulation of transcription, transcription from RNA polymerase II promoter
Post-translation regulation genes
1368171 2.8 Lysyl oxidase Protein modification, copper ion binding oxidoreductase activity, cancer metastasis, granulosa cell differentiation
1374828 1.8 Protein disulfide isomerase-associated 5 Electron transport, protein folding and response to stress
1370859 1.5 Protein disulfide isomerase associated 6 Electron transport, protein folding and electron transport
1398895 1.4 Golgi autoantigen, golgin subfamily a,7 Protein amino acid palmitoylation
1392149 1.3 Transcribed locus Unknown
1368653a 1.3 Parkinson disease (autosomal recessive, early onset) 7 Protein folding, cell proliferation and adult locomotory behavior
1387258a 1.3 Protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Protein methylation, S-adenosylhomocysteine metabolism and protein modification
1386164 1.3 Cell division cycle 2-like 5 (cholinesterase-related cell division controller) Protein phosphorylation, regulation of mitosis and positive regulation of cell proliferation
1398343 1.2 DNAJ (Hsp40) homolog, subfamily A, member 4 Protein folding
1383475 -1.3 Protein phosphatase 1A, magnesium dependent, alpha isoform Protein dephosphorylation, positive regulation of IkB kinase/NFkB cascade
Microtubule cytoskeleton regulation genes
1370154 1.7 Lysozyme Antimicrobial activity in human follicular fluid, ovulation
1390529 1.7 CD83 antigen Defense response, humoral immune response and signal transduction
1375664 1.7 Trinucleotide repeat containing 6 Microtubule-based movement
1369948 1.6 Nerve growth factor receptor associated protein 1 Induction of apoptosis, increase in PCO ovaries
1374321 1.4 Similar to RIKEN cDNA 2700081O15 Unknown
1388711 1.4 Interleukin 13 receptor, alpha 1 Cell surface receptor linked signal transduction
1372330 1.4 Goliath Apoptosis and proteolysis
1372682 1.3 Similar to RIKEN cDNA 2810432L12 Unknown
1372093 1.3 Max interacting protein 1 Unknown
1386952a 1.3 Dynein, cytoplasmic, intermediate chain 2 Microtubule-based movement
1380577 1.3 ATP-binding cassette, sub-family G (WHITE), member 2 Drug transport
1369970 1.3 Vesicle-associated membrane protein 8 Protein complex assembly and vesicle-mediated transport
1367716 1.2 T-cell immunomodulatory protein Unknown
1373090 1.2 Signal sequence receptor, alpha Cotranslational protein targeting to membrane, positive regulation of cell proliferation
1376874a 1.2 Adaptor-related protein complex AP-4, beta 1 Intracellular protein transport, vesicle-mediated transport
1383206 1.2 Component of oligomeric golgi complex 3 Intracellular protein transport
1369549 -1.3 Killer cell lectin-like receptor subfamily K, member 1 Unknown
1371073 -1.7 UDP-Gal: betaGlcNAc beta 1,4-galactosyltransferase, ploypeptide 1 Promote apoptosis, N-acetyllactosaminesynthase activity, beta-N-acetylgluco-saminylglycopeptide beta-1,4-galactosyltransferase activity, carbohydrate metabolism, development of secondary sexual characteristics, extracellular matrix organization and biogenesis, galactose metabolism, integral to membrane, lactose synthase activity, oligosaccharide biosynthesis, transferase activity,
  1. *Fold changes represent difference of gene expression in granulosa cells from follicles containing oocytes with normal developmental competence compared with that with poor developmental competence. "-": down-regulation; others: up-regulation