Figure 2

Trastuzumab sensitivity does not correlate with HER2 expression. A1847, IGROV-1, OVCAR-7, SKOV-3, SKBR-3, and CHO HER2 cells were exposed to trastuzumab (0-75 μg/mL) for 120 hours, and cell proliferation was measured by a WST-1-based colormetric assay. A1847 and SKBR-3 cells were significantly growth inhibited by trastuzumab while IGROV-1, OVCAR-7, SKOV-3, and CHO HER2 cells were not significantly growth inhibited by trastuzumab. Student's T-test was used to determine whether significant differences in cell proliferation exist between untreated and treated cell populations. Asterisk denotes statistical variances (p < 0.05) where treated cells were growth inhibited.