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Table 5 Comparison of ROC–AUCs, sensitivity and specificity for ROMA, CA125 (U/ml) and HE4 (pM), discriminating malignant including borderline tumors from benign tumors

From: High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer

  Premenopausal^ n= 123   Premenopausal^   
  AUC 95% CI n= 123 cutoff sens (%) spec (%)
HE4 0,73 0,58-0,87 ROMA 4,6% 82 75
CA125 0,82 0,73-0,92 CA125 35 59 68
ROMA 0,73 0,58-0,88 HE4 39 82 75
    HE4 60 59 77
    HE4 70 41 89
  Postmenopausal^^ n= 154   Postmenopausal^^   
  AUC 95% CI n= 154 cutoff sens (%) spec (%)
HE4 0,91 0,87-0,96 ROMA 10,4% 99 75
CA125 0,91 0,87-0,96 CA125 35 82 84
ROMA 0,94 0,90-0,98 HE4 70 90 75
    HE4 100 80 86
    HE4 120 72 91
  1. ^Premenopausal = women < 50 year of age.
  2. ^^Postmenopausal = women > 54 year of age.
  3. ROMA cut-off set at fixed specificity 75% as recommended by Moore et al. 2009 among patients with all types and stages of ovarian tumours.