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Table 4 Number of compounds mapping into individual cellular response categories of SOM

From: Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening

 

F

J

M

N

P

Q

R

S

V

(a)

29 (4.2%)

44 (6.4%)

129 (18.7%)

102 (14.8%)

92 (13.3%)

83 (12.0%)

25 (3.6%)

140 (20.3%)

46 (6.7%)

(b)

5 (2.6%)

7 (3.6%)

70 (36.1%)

16 (8.2%)

25 (12.9%)

13 (6.7%)

5 (2.6%)

42 (21.6%)

11 (5.7%)

(c)

3 (1.9%)

5 (3.1%)

62 (38.5%)

16 (9.9%)

19 (11.8%)

9 (5.6%)

3 (1.9%)

35 (21.7%)

9 (5.6%)

(d)

2 (7.4%)

1 (3.7%)

6 (22.2%)

0 (0%)

5 (18.5%)

4 (14.8%)

1 (3.7%)

7 (25.9%)

1 (3.7%)

p-ab

0.3988

0.1653

<0.0001

0.0169

1.0000

0.0365

0.6537

0.6882

0.7412

p-ac

0.2469

0.1326

<0.0001

0.1283

0.6970

0.0163

0.3325

0.6663

0.7235

p-ad

Numbers too small for statistical evaluation

  1. (a) all 793 evaluable compounds (b) 136 CSC inhibitory compounds; (c) 99 CSC and OVCAR-3 co-inhibitory compounds; (d) 32 CSC-specific inhibitory compounds. P-values: Fisher’s exact test for the significance of differences between proportions of compounds in a given cellular response category in 793 compound set (A) and compound subset B (p-AB), C (p-AC), or D (p-AD). [mitosis (M), membrane function (N), nucleic acid metabolism (S), metabolic stress and cell survival (Q), kinases/phosphatases and oxidative stress (P) and 4 unexplored regions (RFJV)].