Table 1 Resistance values determined by clonogenic assay expressed as IC 50 for each cell line and drug(s)
Resistant line | IC 50 of resistant line to either CBN and/or DXL | IC 50 of co-cultured control to either CBN and/or DXL | Fold resistance. Ratio of IC 50 of resistant line/ co-cultured control |
|---|---|---|---|
A2780CBN | 7.77 x 10-5 M CBN | 5.73 x 10-6 M CBN | 13.56 |
| Â | 3.62 x 10-10 M DXL | 5.76 x 10-10 M DXL | 0.63 |
A2780DXL | 3.61 x 10-7 M DXL | 8.91 x 10-11 M DXL | 4051.63 |
| Â | 2.20 x 10-6 M CBN | 6.75 x 10-6 M CBN | 0.33 |
A2780CBNDXL | 8.02 x 10-6 M CBN | 6.37 x 10-7 M CBN | 12.59 |
| Â | 8.02 x 10-9 M DXL | 6.37 x 10-10 M DXL | Â |
A2780CBNDXL | 2.52 x 10-5 M CBN | 2.50 x 10-6 M CBN | 10.08 |
A2780CBNDXL | 1.47 x 10-8 M DXL | 1.84 x 10-9 M DXL | 7.99 |