Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome

Table 4 ACTH stimulated hormone levels and their AUC values among different phenotypes of PCOS

Parameters	PHO	OH	PH	PO	P
Parameters	(n = 50)	(n = 32)	(n = 23)	(n = 14)	(overall)
DHEA ₀	15.9 ± 7.9	19.3 ± 7.7^a	17.2 ± 7.3^b	12.2 ± 7.5	<0.05
DHEA ₃₀	23.7 ± 6.7^b	24.9 ± 6.7^a	25.5 ± 5.5^a	18.2 ± 6.4	<0.05
DHEA ₆₀	24.7 ± 6.3*	27.2 ± 5.9^b	26.3 ± 5.2	21.8 ± 8.1	<0.05
17-OHP ₀ (ng/ml)	1.6 ± 1.1	1.4 ± 0.7	1.6 ± 1.3	0.9 ± 0.3	0.078
17-OHP ₃₀ (ng/ml)	3.7 ± 1.7^b	3.7 ± 1.2^a	3.6 ± 1.5^b	2.6 ± 1.1	<0.05
17-OHP ₆₀ (ng/ml)	4.3 ± 1.9	4.2 ± 1.5	4.3 ± 1.8	3.1 ± 1.1	0.072
A4 ₀ (ng/ml)	3.4 ± 1.9	3.2 ± 1.2	2.8 ± 0.8	2.2 ± 1.0	NS
A4 ₃₀ (ng/ml)	4.3 ± 2.0^a	4.3 ± 1.8^b	4.0 ± 1.3^b	2.9 ± 0.9	<0.05
A4 ₆₀ (ng/ml)	4.7 ± 1.9^a	4.3 ± 1.7^b	4.4 ± 1.4^a	3.1 ± 1.0	<0.01
F ₀ (μg/dl)	14.4 ± 6.3	14.6 ± 6.0	13.9 ± 5.6	11.6 ± 4.4	NS
F ₃₀ (μg/dl)	26.2 ± 4.6	28.6 ± 5.1	25.9 ± 6.1	25.2 ± 4.6	NS
F ₆₀ (μg/dl)	30.4 ± 6.7	32.3 ± 5.7	31.5 ± 5.9	29.5 ± 5.5	NS
AUC _DHEA (ng/ml × 60 min)	1314 ± 390	1437 ± 348^a	1415 ± 297^a	1057 ± 397	<0.05
AUC _17-OHP (ng/ml × 60 min)	198 ± 90^a	195 ± 62^a	194 ± 85^b	140 ± 51	<0.05
AUC _A4 (ng/ml × 60 min)	254 ± 117^a	240 ± 93^b	230 ± 69^a	164 ± 55	<0.05
AUC _F (μg/dl × 60 min)	1466 ± 312	1563 ± 298	1456 ± 331	1372 ± 253	NS

Results are expressed as mean ± SD. NS not significant, AUC area under the curve, PHO polycystic ovaries, oligo-anovulation and hyperandrogenism, OH oligo-anovulation and hyperandrogenism, PH polycystic ovaries and hyperandrogenism, PO polycystic ovaries and oligo-anovulation, DHEA, dehydroepiandrosterone, 17-OHP 17-hydroxyprogesterone, A4 androstenedione, F cortisol.
^a P <0.01 vs. PO.
^b P <0.05 vs. PO.
*P <0.05 vs. OH.

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