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Table 4 ACTH stimulated hormone levels and their AUC values among different phenotypes of PCOS

From: Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome

Parameters PHO OH PH PO P
(n = 50) (n = 32) (n = 23) (n = 14) (overall)
DHEA 0 15.9 ± 7.9 19.3 ± 7.7a 17.2 ± 7.3b 12.2 ± 7.5 <0.05
DHEA 30 23.7 ± 6.7b 24.9 ± 6.7a 25.5 ± 5.5a 18.2 ± 6.4 <0.05
DHEA 60 24.7 ± 6.3* 27.2 ± 5.9b 26.3 ± 5.2 21.8 ± 8.1 <0.05
17-OHP 0 (ng/ml) 1.6 ± 1.1 1.4 ± 0.7 1.6 ± 1.3 0.9 ± 0.3 0.078
17-OHP 30 (ng/ml) 3.7 ± 1.7b 3.7 ± 1.2a 3.6 ± 1.5b 2.6 ± 1.1 <0.05
17-OHP 60 (ng/ml) 4.3 ± 1.9 4.2 ± 1.5 4.3 ± 1.8 3.1 ± 1.1 0.072
A4 0 (ng/ml) 3.4 ± 1.9 3.2 ± 1.2 2.8 ± 0.8 2.2 ± 1.0 NS
A4 30 (ng/ml) 4.3 ± 2.0a 4.3 ± 1.8b 4.0 ± 1.3b 2.9 ± 0.9 <0.05
A4 60 (ng/ml) 4.7 ± 1.9a 4.3 ± 1.7b 4.4 ± 1.4a 3.1 ± 1.0 <0.01
F 0 (μg/dl) 14.4 ± 6.3 14.6 ± 6.0 13.9 ± 5.6 11.6 ± 4.4 NS
F 30 (μg/dl) 26.2 ± 4.6 28.6 ± 5.1 25.9 ± 6.1 25.2 ± 4.6 NS
F 60 (μg/dl) 30.4 ± 6.7 32.3 ± 5.7 31.5 ± 5.9 29.5 ± 5.5 NS
AUC DHEA (ng/ml × 60 min) 1314 ± 390 1437 ± 348a 1415 ± 297a 1057 ± 397 <0.05
AUC 17-OHP (ng/ml × 60 min) 198 ± 90a 195 ± 62a 194 ± 85b 140 ± 51 <0.05
AUC A4 (ng/ml × 60 min) 254 ± 117a 240 ± 93b 230 ± 69a 164 ± 55 <0.05
AUC F (μg/dl × 60 min) 1466 ± 312 1563 ± 298 1456 ± 331 1372 ± 253 NS
  1. Results are expressed as mean ± SD. NS not significant, AUC area under the curve, PHO polycystic ovaries, oligo-anovulation and hyperandrogenism, OH oligo-anovulation and hyperandrogenism, PH polycystic ovaries and hyperandrogenism, PO polycystic ovaries and oligo-anovulation, DHEA, dehydroepiandrosterone, 17-OHP 17-hydroxyprogesterone, A4 androstenedione, F cortisol.
  2. a P <0.01 vs. PO.
  3. b P <0.05 vs. PO.
  4. *P <0.05 vs. OH.