Current status and implications of microRNAs in ovarian cancer diagnosis and therapy

Table 2 miRNA profile of subtypes of ovarian cancer

Type of ovarian cancer	Up-regulated miRNA	Down-regulated miRNA	References
Serous	miR-200a, miR-200b, miR-200c, miR-141, miR-93, miR-21,miR-519a, miR-214	let7-b, miR-99a, miR-125b, miR-22, miR-31, miR-34a/b/c	[42, 47, 51, 86, 102, 106, 108, 109]
Clear Cell	miR-519a, miR-182, miR-30a,miR-21, miR-200a, miR-200c	miR-100, miR-22, miR-34a/b/c, miR-214	[42, 51, 83, 109]
Mucinous	miR-153, miR-485-5p		[109]
Endometrioid	miR-200a, miR-200b, miR-200c, miR-141		[42]

Most of the miRNA profiling has been done on the serous and clear cell ovarian carcinoma. miR-200 family stands out as the up-regulated miRNA in most types of ovarian cancer. miR-100 plays a specific role in clear cell ovarian carcinoma.

ISSN: 1757-2215