Table 2 Selected genes shown to be differentially expressed between Foc3 and MFOC3 cells by transcriptomic profiling.
Downregulated in MFOC3 | |||
|---|---|---|---|
Gene Symbol | Gene Name | Fold Change | Function |
KRT19 | Keratin 19 | 0.10 | cytoskeleton |
KRT14 | Keratin 14 | 0.13 | cytoskeleton |
ITGB8 | Integrin beta 8 | 0.19 | cell and matrix adhesion |
KRT13 | Keratin 18 | 0.24 | cytoskeleton |
KRT18 | Keratin 13 | 0.30 | cytoskeleton |
CASP1 | Caspase 1 | 0.33 | IL1beta convertase |
ITGA9 | Integrin alpha 9 | 0.39 | cell and matrix adhesion |
ESR1 | Estrogen receptor 1 | 0.41 | hormone receptor |
NME1 | Non-metastatic protein 1 | 0.49 | inhibitor of metastasis |
Upregulated in MFOC3 | |||
Gene Symbol | Gene Name | Fold Change | Function |
PAI2 | Plasminogen activator inhibitor type II | 25.56 | proteolytic enzyme |
IL1B | Interleukin 1beta | 11.11 | cytokine |
TNF | Tumor necrosis factor | 7.88 | cytokine |
API2 | Apoptosis inhibitor 2 | 7.44 | inhibition of apoptosis |
TGFB1 | Transforming growth factor | 5.30 | cell adhesion regulation |
PLAU | Plasminogen activator, urokinase | 4.50 | proteolytic enzyme |
FGFR1 | Fibroblast factor receptor 1 | 4.34 | growth factor receptor |
API1 | Apoptosis inhibitor 1 | 4.26 | inhibition of apoptosis |
ITGA8 | Integrin alpha 8 | 3.95 | cell and matrix adhesion |
LAMB1 | Laminin, beta1 | 3.88 | extracellular matrix |
FGF1 | Fibroblast growth factor 1 | 3.79 | growth factor |
SDC1 | Syndecan 1 | 3.19 | membrane protein |
CTNNB1 | Catenin, beta1 | 3.03 | cell adhesion |