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Figure 5 | Journal of Ovarian Research

Figure 5

From: Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway

Figure 5

Inhibition of MAPK/Erk signaling reduces insulin-induced OSE hyperplasia. Organoids were cultured 7d in media containing the MEK1/2 inhibitor 10 μM UO126, 10 μM UO126 plus 5 μg/ml insulin, or 10 μM UO126 plus 5 μg/ml IGF-I. Tissues were stained for expression of CK8 and BrdU (A) and the percentage of proliferating OSE was quantified (B). All images are 400X. Data shown represent SEM. Statistical differences (P<0.05) are between groups labeled a and b.

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Journal of Ovarian Research

ISSN: 1757-2215

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