Figure 8From: Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway Culture of organoids with insulin or IGF-I disorders collagen-IV organization. Organoids were cultured for 7d in the indicated media. Tissues were stained for expression of collagen IV. All images are 100X.Back to article page