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Table 6 Change in QoL measures and associated HRs for death

From: Longitudinal health-related quality of life assessment: implications for prognosis in ovarian cancer

Change variable QoL change mean (SD) Univariate Multivariate
HR (95% CI) P HR (95% CI) P
General quality of life      
Global −0.5 (31.1) 0.89 (0.81 – 0.98) 0.01* 0.90 (0.81 – 0.99) 0.03*
General function      
Physical −1.2 (25.6) 1.0 (0.90 – 1.10) 0.99 1.03 (0.82 – 1.23) 0.79
Role 0.0 (36.6) 0.98 (0.92 – 1.05) 0.67 1.11 (0.95 – 1.28) 0.18
Emotional 1.0 (32.2) 0.97 (0.88 – 1.06) 0.48 0.94 (0.78 – 1.09) 0.43
Cognitive −1.2 (31.2) 1.02 (0.93 – 1.10) 0.69 1.18 (0.89 – 1.33) 0.23
Social −0.9 (39.9) 0.97(0.91 – 1.03) 0.36 0.90 (0.79 – 1.01) 0.09
General symptom      
Fatigue 2.1 (31.0) 1.02 (0.94 – 1.11) 0.58 0.96 (0.73 – 1.19) 0.72
Nausea/vomiting 1.2 (33.1) 1.02 (0.92 – 1.12) 0.69 0.80 (0.75 – 1.03) 0.08
Pain 1.3 (35.4) 1.02 (0.93 – 1.10) 0.71 0.97 (0.83 – 1.11) 0.68
Dyspnea −0.2 (36.0) 0.97 (0.90 – 1.05) 0.50 0.97 (0.85 – 1.10) 0.66
Insomnia −4.6 (38.8) 1.02 (0.95 – 1.09) 0.62 1.08 (0.97 – 1.19) 0.15
Appetite loss 0.9 (41.8) 1.06 (1.0 – 1.12) 0.06 1.20 (1.06 – 1.35) 0.005*
Constipation 1.2 (34.8) 1.06 (0.98 – 1.14) 0.12 1.13 (1.02 – 1.24) 0.02*
Diarrhea −4.3 (28.5) 1.02 (0.91 – 1.13) 0.74 1.07 (0.93 – 1.20) 0.33
Financial 2.4 (39.7) 0.96 (0.90 – 1.03) 0.29 0.88 (0.78 – 1.02) 0.08
  1. • HRs correspond to a 10-point increment for QoL scores.
  2. • 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
  3. • Multivariate model (for change in general function and symptom variables combined) adjusted for prior treatment history and all QoL change variables.
  4. • Multivariate model for change in global QoL adjusted for prior treatment history.
  5. • *P <0.05.