Longitudinal health-related quality of life assessment: implications for prognosis in ovarian cancer

Table 6 Change in QoL measures and associated HRs for death

Change variable	QoL change mean (SD)	Univariate		Multivariate
Change variable	QoL change mean (SD)	HR (95% CI)	P	HR (95% CI)	P
General quality of life
Global	−0.5 (31.1)	0.89 (0.81 – 0.98)	0.01*	0.90 (0.81 – 0.99)	0.03*
General function
Physical	−1.2 (25.6)	1.0 (0.90 – 1.10)	0.99	1.03 (0.82 – 1.23)	0.79
Role	0.0 (36.6)	0.98 (0.92 – 1.05)	0.67	1.11 (0.95 – 1.28)	0.18
Emotional	1.0 (32.2)	0.97 (0.88 – 1.06)	0.48	0.94 (0.78 – 1.09)	0.43
Cognitive	−1.2 (31.2)	1.02 (0.93 – 1.10)	0.69	1.18 (0.89 – 1.33)	0.23
Social	−0.9 (39.9)	0.97(0.91 – 1.03)	0.36	0.90 (0.79 – 1.01)	0.09
General symptom
Fatigue	2.1 (31.0)	1.02 (0.94 – 1.11)	0.58	0.96 (0.73 – 1.19)	0.72
Nausea/vomiting	1.2 (33.1)	1.02 (0.92 – 1.12)	0.69	0.80 (0.75 – 1.03)	0.08
Pain	1.3 (35.4)	1.02 (0.93 – 1.10)	0.71	0.97 (0.83 – 1.11)	0.68
Dyspnea	−0.2 (36.0)	0.97 (0.90 – 1.05)	0.50	0.97 (0.85 – 1.10)	0.66
Insomnia	−4.6 (38.8)	1.02 (0.95 – 1.09)	0.62	1.08 (0.97 – 1.19)	0.15
Appetite loss	0.9 (41.8)	1.06 (1.0 – 1.12)	0.06	1.20 (1.06 – 1.35)	0.005*
Constipation	1.2 (34.8)	1.06 (0.98 – 1.14)	0.12	1.13 (1.02 – 1.24)	0.02*
Diarrhea	−4.3 (28.5)	1.02 (0.91 – 1.13)	0.74	1.07 (0.93 – 1.20)	0.33
Financial	2.4 (39.7)	0.96 (0.90 – 1.03)	0.29	0.88 (0.78 – 1.02)	0.08

• HRs correspond to a 10-point increment for QoL scores.
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
• Multivariate model (for change in general function and symptom variables combined) adjusted for prior treatment history and all QoL change variables.
• Multivariate model for change in global QoL adjusted for prior treatment history.
• *P <0.05.

ISSN: 1757-2215