Figure 4
Effect of AT 1 -AA on angiogenesis of the CAM. Relative to the saline control (A), AT1-AA significantly increased microvascular density of the CAM (B) to a comparable level as did by Ang II (C). Enhancement of microvascular density by AT1-AA was blocked either by AT1-AA-ECII (D) or Ang II AT1 receptor antagonist, losartan (E). Values are mean ± SE. n = 6 for each group. *p < 0.05 vs. saline control (Nor); †P < 0.05 vs. AT1-AA and Ang II. HPF = high power field (x400).