Figure 2

Forced ST6Gal-I expression protects OV4 cells from cisplatin-induced cell death. (A) Compared with Par or EV cells, OV4 cells with forced ST6Gal-I expression (ST6) exhibit attenuated cisplatin-induced cell death, as measured by ATP content. Means and S.E.M.s are shown for a representative experiment, with three independent experiments performed, and each experiment performed in triplicate. (B) ST6 cells have reduced levels of cleaved caspase-3 (representing caspase activation) following cisplatin treatment.