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Table 1 Molecular pathways regulated by miRNAs in DHT-treated ovaries

From: Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model

Molecular pathways List of miRNA
Ovarian cancer signalling rno-miR-96↓, rno-miR-25↑, rno-miR-24↓, rno-miR-221↓, rno-miR-21↓, rno-miR-183↓, rno-miR-182↓, rno-miR-132↓, rno-let-7d↑
Androgen signalling rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-183↓, rno-miR-184↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↓, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓
Androgen & estrogen metabolism rno-miR-96↓, rno-let-7d↑, rno-miR-24↓, rno-miR-26b↑, rno-miR-21↓, rno-miR-26b↑, rno-miR-31↓
Aldosterone signalling (epithelial cells) rno-miR-182↓, rno-miR-183↓, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓
VEGF signalling rno-miR-96↓, rno-miR-182↓, rno-miR-31↓
RhoA signalling rno-miR-132↓, rno-miR-182v, rno-miR-183↓, rno-miR-384-3p↓, rno-miR-96↓
14-3-3-mediated Signalling rno-miR-96↓, rno-miR-384-3p↓, rno-miR-335↑, rno-miR-31↓, rno-miR-26b↑, rno-miR-25↑, rno-miR-24↓, rno-miR-221↓, rno-miR-21↓, rno-miR-184↓, rno-miR-183↓, rno-miR-182↓, rno-miR-132↓, rno-let-7d↑
Apoptosis signalling rno-miR-25↑, rno-let-7d↑, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓
Calcium signalling rno-miR-384-3p↓, rno-let-7d↓, rno-miR-132v, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-2↓5, rno-miR-26b↑, rno-miR-384-3p↓, rno-miR-96↓
Estrogen receptor signalling rno-miR-182↓, rno-miR-96↓, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓
FGF Signalling rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-384-3p↓, rno-miR-96
G-Protein coupled receptor signalling rno-let-7d↑, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓
Focal adhesion kinase-1 (FAKn) rno-miR-25↑, rno-miR-384-3p↓, rno-miR-96↓, rno-miR-183↓, rno-miR-26b↑, rno-miR-182↓, rno-miR-21↓, rno-miR-24↓, rno-miR-31↓
Glucocorticoid receptor Signalling rno-let-7d↑, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑
Growth hormone Signalling rno-let-7d↑, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑
Inositol phosphate metabolism rno-miR-335↑, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓
P53 signalling rno-miR-132↓, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31v↓, rno-miR-96↓
  1. (↑ denotes upregulation and ↓ denotes downregulation).