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Table 1 Molecular pathways regulated by miRNAs in DHT-treated ovaries

From: Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model

Molecular pathways

List of miRNA

Ovarian cancer signalling

rno-miR-96↓, rno-miR-25↑, rno-miR-24↓, rno-miR-221↓, rno-miR-21↓, rno-miR-183↓, rno-miR-182↓, rno-miR-132↓, rno-let-7d↑

Androgen signalling

rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-183↓, rno-miR-184↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↓, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓

Androgen & estrogen metabolism

rno-miR-96↓, rno-let-7d↑, rno-miR-24↓, rno-miR-26b↑, rno-miR-21↓, rno-miR-26b↑, rno-miR-31↓

Aldosterone signalling (epithelial cells)

rno-miR-182↓, rno-miR-183↓, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓

VEGF signalling

rno-miR-96↓, rno-miR-182↓, rno-miR-31↓

RhoA signalling

rno-miR-132↓, rno-miR-182v, rno-miR-183↓, rno-miR-384-3p↓, rno-miR-96↓

14-3-3-mediated Signalling

rno-miR-96↓, rno-miR-384-3p↓, rno-miR-335↑, rno-miR-31↓, rno-miR-26b↑, rno-miR-25↑, rno-miR-24↓, rno-miR-221↓, rno-miR-21↓, rno-miR-184↓, rno-miR-183↓, rno-miR-182↓, rno-miR-132↓, rno-let-7d↑

Apoptosis signalling

rno-miR-25↑, rno-let-7d↑, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓

Calcium signalling

rno-miR-384-3p↓, rno-let-7d↓, rno-miR-132v, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-2↓5, rno-miR-26b↑, rno-miR-384-3p↓, rno-miR-96↓

Estrogen receptor signalling

rno-miR-182↓, rno-miR-96↓, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓

FGF Signalling

rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-384-3p↓, rno-miR-96

G-Protein coupled receptor signalling

rno-let-7d↑, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31↓, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓

Focal adhesion kinase-1 (FAKn)

rno-miR-25↑, rno-miR-384-3p↓, rno-miR-96↓, rno-miR-183↓, rno-miR-26b↑, rno-miR-182↓, rno-miR-21↓, rno-miR-24↓, rno-miR-31↓

Glucocorticoid receptor Signalling

rno-let-7d↑, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑

Growth hormone Signalling

rno-let-7d↑, rno-miR-182↓, rno-miR-183↓, rno-miR-21↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑

Inositol phosphate metabolism

rno-miR-335↑, rno-let-7d↑, rno-miR-132↓, rno-miR-182↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-335↑, rno-miR-384-3p↓, rno-miR-96↓

P53 signalling

rno-miR-132↓, rno-miR-183↓, rno-miR-21↓, rno-miR-221↓, rno-miR-24↓, rno-miR-25↑, rno-miR-26b↑, rno-miR-31v↓, rno-miR-96↓

  1. (↑ denotes upregulation and ↓ denotes downregulation).