Table 2 Overall and stratified meta-analysis of the association between the Tyr113His mEH polymorphism and ovarian cancer risk
From: mEH Tyr113His polymorphism and the risk of ovarian cancer development
Genotype comparison | OR [95% CI] | Z (P value) | Heterogeneity of study design | Analysis model | ||
|---|---|---|---|---|---|---|
χ 2 | df (P value) | I 2 | ||||
Total (2566 cases, 2839 controls) | ||||||
C-allele vs. T-allele | 0.99 [0.83, 1.17] | 0.17 (0.86) | 9.42 | 4 (0.05) | 58% | Random |
CC vs. TT | 1.20 [1.01, 1.43] | 2.05 (0.04) | 6.21 | 4 (0.18) | 36% | Fixed |
CC vs. TT + TC | 1.20 [1.01, 1.41] | 2.11 (0.03) | 6.04 | 4 (0.20) | 34% | Fixed |
TT vs. CC + TC | 1.04 [0.83, 1.29] | 0.33 (0.74) | 9.05 | 4 (0.06) | 56% | Random |
Caucasian (2480 cases, 2665 controls) | ||||||
C-allele vs. T-allele | 1.01 [0.85, 1.21] | 0.13 (0.89) | 7.57 | 3 (0.06) | 60% | Random |
CC vs. TT | 1.25 [1.04, 1.50] | 2.36 (0.02) | 4.22 | 3 (0.24) | 29% | Fixed |
CC vs. TT + TC | 1.26 [1.05, 1.50] | 2.56 (0.01) | 2.99 | 3 (0.39) | 0% | Fixed |
TT vs. CC + TC | 1.04 [0.80, 1.34] | 0.28 (0.78) | 8.73 | 3 (0.03) | 66% | Random |
Chinese (86 cases, 174 controls) | ||||||
C-allele vs. T-allele | 0.83 [0.58, 1.20] | 0.99 (0.32) | ||||
CC vs. TT | 0.78 [0.42, 1.46] | 0.77 (0.44) | ||||
CC vs. TT + TC | 0.77 [0.45, 1.30] | 0.99 (0.32) | ||||
TT vs. CC + TC | 1.13 [0.65, 1.99] | 0.44 (0.66) | ||||