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Table 2 Overall and stratified meta-analysis of the association between the Tyr113His mEH polymorphism and ovarian cancer risk

From: mEH Tyr113His polymorphism and the risk of ovarian cancer development

Genotype comparison OR [95% CI] Z (P value) Heterogeneity of study design Analysis model
χ 2 df (P value) I 2
Total (2566 cases, 2839 controls)
C-allele vs. T-allele 0.99 [0.83, 1.17] 0.17 (0.86) 9.42 4 (0.05) 58% Random
CC vs. TT 1.20 [1.01, 1.43] 2.05 (0.04) 6.21 4 (0.18) 36% Fixed
CC vs. TT + TC 1.20 [1.01, 1.41] 2.11 (0.03) 6.04 4 (0.20) 34% Fixed
TT vs. CC + TC 1.04 [0.83, 1.29] 0.33 (0.74) 9.05 4 (0.06) 56% Random
Caucasian (2480 cases, 2665 controls)
C-allele vs. T-allele 1.01 [0.85, 1.21] 0.13 (0.89) 7.57 3 (0.06) 60% Random
CC vs. TT 1.25 [1.04, 1.50] 2.36 (0.02) 4.22 3 (0.24) 29% Fixed
CC vs. TT + TC 1.26 [1.05, 1.50] 2.56 (0.01) 2.99 3 (0.39) 0% Fixed
TT vs. CC + TC 1.04 [0.80, 1.34] 0.28 (0.78) 8.73 3 (0.03) 66% Random
Chinese (86 cases, 174 controls)
C-allele vs. T-allele 0.83 [0.58, 1.20] 0.99 (0.32)  
CC vs. TT 0.78 [0.42, 1.46] 0.77 (0.44)  
CC vs. TT + TC 0.77 [0.45, 1.30] 0.99 (0.32)  
TT vs. CC + TC 1.13 [0.65, 1.99] 0.44 (0.66)