Table 1 Summary of the papers included in the analysis evaluating the relationship between zygote morphology and biological and clinical outcomes
Authors | Design | Age (yrs) | Zygotes (n.) | ART procedure | TOPI | Zygote score | Outcome measures | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EQ | CS | BS | IR | PR | D/LBR | ECS | |||||||
Scott et al. 2000 [10] | P | <43 | 3,701 | IVF/ICSI | NA | Modified from Scott and Smith, 1998 | Yes | NA | Yes | Yes | Yes | NA | NA |
Wittemer et al. 2000 [11] | P | NA | 1,000 | IVF/ICSI | 18h | Modified from Tesarik and Greco, 1999 | Yes | NA | NA | NA | Yes | NA | NA |
Tesarik et al. 2000 [12] | R | NA | 350 | ICSI | 14–17h | Tesarik and Greco, 1999 | Not | Not | NA | Yes | Yes | NA | NA |
Ludwig et al. 2000 [13] | P | NA | 405 | IVF/ICSI | 16–18h | Scott and Smith, 1998 | Yes | NA | NA | NA | Yes | NA | NA |
Balaban et al. 2001 [14] | R | NA | 86 | ICSI | 14–17h | Tesarik and Greco, 1999 | Yes | Yes | Yes | Yes | Yes | NA | NA |
Salumets et al. 2001 [15] | P | NA | 2,284 | IVF/ICSI | 16–18h | Scott and Smith, 1998/Tesarik and Greco, 1999 | Not | Yes* | NA | Not | Not | NA | NA |
Montag et al. 2001 [16] | P | NA | 1,114 | IVF/ICSI | 16–20h | Modified from Tesaik and Greco, 1999 | NA | NA | NA | Yes | Yes | NA | NA |
De Placido et al. 2002 [17] | R | NA | 1,171 | ICSI | 16–20h | Combination of Sadowy, 1998, Scott and Smith, 1998, Tesarik and Greco, 1999, Scott, 2000, and Wittemer, 2000 | Not | Not | NA | Not | Not | NA | NA |
Zollner et al. 2002 [18] | P | 33.4±4.1 | 1,119 | IVF/ICSI | 16–18h | Number, juxtaposition and size of PN, number and alignment of NPBs | NA | Yes | Yes°° | NA | NA | NA | NA |
Gianaroli et al. 2003 [19] | P | ≥36 | 631 | IVF/ICSI | 16h | Gianaroli, 2003 | Yes | Yes | NA | Yes | Yes | NA | Yes |
Chen et al. 2003 [20] | P | 368 | IVF | 18–21h | Modified from Scott, 2000 | Not | NA | NA | NA | NA | NA | Yes | |
Nagy et al. 2003 [21] | P/R | 25–40 | 912 | ICSI | 12–21h§ | Size of PN, number and polarization of NPBs | Yes° (only in day 3) | Yes° (only in day 2) | NA | Yes# | Yes# | NA | NA |
Scott et al. 2003 [22] | R | <43 | 3,882 | IVF/ICSI | 16–18h | Scott, 2000 | NA | Yes | Yes | NA | NA | NA | NA |
Lan et al. 2003 [23] | R | NA | 1,894 | IVF/ICSI | 16–18h | Scott, 2000 | Yes | Yes | Yes | Yes | Yes | NA | NA |
Gámiz et al. 2003 [24] | P | NA | 888 | ICSI | 16–18h | Size of PN, number, distribuiton and synchrony of NPBs | NA | Yes*** | NA | NA | NA | NA | Yes*** |
Jaroudi et al. 2004 [25] | P | NA | 131 | IVF/ICSI | 15–18h | Tesarik, 2000 | Not | NA | NA | NA | Not | NA | NA |
Kattera et al. 2004 [26] | P | 35.4±3.6 (IVF) 35.1±3.4 (ICSI) | 2,714 | IVF/ICSI | 18–20h | PN orientation | Yes | Yes | NA | Not | Not | NA | NA |
Balaban 2004 [27] | R | NA | 309 | IVF/ICSI | 17h | Modified from Tesarik and Greco, 1999 | Yes | Yes | Yes | NA | NA | NA | Yes |
Payne et al. 2005 [28] | P | ≤42 | 552 | IVF/ICSI | 16–18h | Scott, 2000 | Not | Not | NA | Not | Not | NA | NA |
Edirisinghe et al. 2005 [29] | P | ≥37 | 952 | IVF/ICSI | 16–18h | Scott, 2000 | Yes | Yes | NA | NA | NA | NA | Yes |
James et al. 2006 [30] | R | NA | 3,333 | IVF/ICSI | 16–18h | Combination of Sadowy, 1998 and Scott, 2000 | Not | NA | NA | Not | Not | Not | NA |
Sjöblom et al. 2006 [31] | R | NA | 1,961 | IVF/ICSI | 16–18h | PBs, NPBs and PN | NA | NA | Yes | NA | NA | NA | NA |
Chen et al. 2006 [32] | P | 35.7±3.7 (IVF) 35.5±3.4 (ICSI) | 1,186 | IVF/ICSI | 18–20h | PN, PBs and NPBs | NA | Yes | NA | Not | Not | NA | NA |
Gianaroli et al. 2007 [33] | R | 38.2±3.7 (IVF) 39.0±3.5 (ICSI) | 2,535 | ICSI | 16h | Gianaroli, 2003 | Yes | NA | NA | Yes | NA | NA | Yes |
Arroyo et al. 2007 [34] | P | 33.1±2.93 (IVF) <39 (ICSI) | 569 | IVF/ICSI | 14–23h | Tesarik and Greco, 1999 / Scott, 2000 | Yes | NA | NA | Not | Not | NA | NA |
Guerif et al. 2007 [35] | P | NA | 4,042 | IVF/ICSI | 18–20h | Modified from Tesarik and Greco, 1999 | NA | NA | Not | NA | NA | NA | NA |
Scott et al. 2007 [36] | P | <38 | 2,528 | IVF/ICSI | 17–18h | Scott, 2000 | NA | NA | NA | Yes | Yes | Yes | NA |
Depa–Martynow et al. 2007 [37] | P | NA | 787 | IVF | 16–18h | Scott, 2000 | Yes | NA | NA | NA | NA | NA | NA |
Nicoli et al. 2007 [38] | R | 23–41 | 1,032 | IVF/ICSI | 18–20h | Modified from Scott, 2000 and Gianaroli, 2003 | Not | NA | NA | Not | Not | NA | NA |
Álvarez et al. 2008 [39] | R | 35.0±3.5 | 883 | IVF/ICSI | 16–18h | Tesarik and Greco, 1999 | Yes | NA | NA | Yes | Yes | NA | NA |
Liu et al. 2008 [40] | P | 30.4±3.71 (IVF) 30.1±3.79 (ICSI) | 2,836 | IVF/ICSI | 16–20h | Scott, 2000 | Yes | Yes | NA | Yes | Not | NA | NA |
Qian et al. 2008 [41] | P | NA | 973 | IVF/ICSI | 18–18h | Scott, 2000/Lan, 2003 | Not | NA | NA | NA | NA | NA | NA |
Brezinova et al. 2009 [42] | R | <39 | 1,954 | IVF/ICSI | 16–20h | Modified from Tesarik and Greco, 1999 | NA | NA | NA | Not | Not | NA | NA |
Maille et al. 2009 [43] | P | 40.1±1.3 (IVF) 27.1±1.4 (ICSI) | 301 | ICSI | 16–18h | Gianaroli, 2003 | Not | Yes ** | NA | Yes | Yes ** | NA | NA |
Zamora et al. 2010 [44] | P | NA | 2,105 | IVF/ICSI | 16–18h | PN size, NPBs and PBs | NA | Yesç | NA | NA | NA | NA | NA |
Weitzman et al. 2010 [45] | P | <36 | 852 | IVF/ICSI | 18–20h | Tesarik and Greco/Scott, 2000 | NA | NA | NA | Not | NA | NA | NA |
Nicoli et al. 2010 [46] | R | 35.9±4.0 | 1,078 | IVF/ICSI | 18–20h | Gianaroli, 2003 | Not | Not | NA | NA | Not | Not | NA |
Bar–Yoseph et al. 2011 [47] | R | 31.1±5.0 | 1,516 | IVF/ICSI | 17–18h | Scott, 2000 | NA | NA | NA | Not | NA | NA | NA |
Aydin et al. 2011 [48] | P | 29.8±3.5 | 487 | ICSI | 16–18h | Modifed from Tesarik and Greco, 1999/Scott, 2000 | NA | Not | NA | NA | NA | NA | NA |
Nicoli et al. 2013 [49] | R | 36.6±3.9 | 755 | IVF/ICSI | 18–20h | Gianaroli, 2003 | NA | NA | NA | NA | Not | Not | NA |